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Study · Animal study (in vivo) · mouse · 2008

5 results

Teriparatide (1-34 human PTH) regulation of osterix during fracture repair.

Kaback LA, Soung do Y, Naik A, Geneau G, Schwarz EM, Rosier RN, O'Keefe RJ, Drissi H

Journal of cellular biochemistry1 Sept 2008Cited by 63 (Europe PMC)

PMID18494002 (opens in a new tab)PMCIDPMC3337675 (opens in a new tab)DOI10.1002/jcb.21816 (opens in a new tab)PepBankPUB-18494002
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, systemic teriparatide accelerated fracture healing compared with controls.

    In plain wordsIn mice, teriparatide accelerated fracture healing compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseFracture healing
    Study

    mousen: not reported in source

    Fracture repair
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 microg/kg · injection · Up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Systemic teriparatide treatments also accelerated fracture healing in these mice concomitantly with increased Osx expression in the PTH treated fracture calluses compared to controls.
    2 context sentences
    Summary · context
    Bone marrow cells from 7 days 40 microg/kg of teriparatide treated or saline control mice were cultured and Osx and osteoblast phenotypic gene expression assessed by real-time RT-PCR in these cells.
    Summary · context
    Fractured animals injected daily with either saline or 40 microg/kg of teriparatide for up to 21 days were X-rayed and histological assessment performed, as well as immunohistochemical analyses of the Osx expression in the fracture callus.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, systemic teriparatide increased osterix expression in fracture calluses compared with controls.

    In plain wordsIn mice, teriparatide increased osterix expression at the fracture compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseFracture callus osterix expression
    Study

    mousen: not reported in source

    Fracture repair
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 microg/kg · injection · Up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Systemic teriparatide treatments also accelerated fracture healing in these mice concomitantly with increased Osx expression in the PTH treated fracture calluses compared to controls.
    2 context sentences
    Summary · context
    Bone marrow cells from 7 days 40 microg/kg of teriparatide treated or saline control mice were cultured and Osx and osteoblast phenotypic gene expression assessed by real-time RT-PCR in these cells.
    Summary · context
    Fractured animals injected daily with either saline or 40 microg/kg of teriparatide for up to 21 days were X-rayed and histological assessment performed, as well as immunohistochemical analyses of the Osx expression in the fracture callus.
  3. 03LabEx vivo tissueMechanism

    In mice, systemic teriparatide increased osterix expression in isolated marrow-derived MSCs.

    In plain wordsIn lab tests, marrow cells from teriparatide-treated mice had higher osterix expression than cells from saline-treated mice.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMarrow MSC osterix expression
    Study

    mousen: not reported in source

    Cultured marrow-derived MSCs from teriparatide- or saline-treated mice
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 microg/kg · injection · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Our data shows that Osx and Runx2 are up-regulated in marrow-derived MSCs isolated from mice systemically treated with teriparatide.
    2 context sentences
    Summary · context
    Bone marrow cells from 7 days 40 microg/kg of teriparatide treated or saline control mice were cultured and Osx and osteoblast phenotypic gene expression assessed by real-time RT-PCR in these cells.
    Summary · context
    Fractured animals injected daily with either saline or 40 microg/kg of teriparatide for up to 21 days were X-rayed and histological assessment performed, as well as immunohistochemical analyses of the Osx expression in the fracture callus.
  4. 04LabEx vivo tissueMechanism

    In mice, systemic teriparatide increased Runx2 expression in isolated marrow-derived MSCs.

    In plain wordsIn lab tests, marrow cells from teriparatide-treated mice had higher Runx2 expression than cells from saline-treated mice.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMarrow MSC Runx2 expression
    Study

    mousen: not reported in source

    Cultured marrow-derived MSCs from teriparatide- or saline-treated mice
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 microg/kg · injection · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Our data shows that Osx and Runx2 are up-regulated in marrow-derived MSCs isolated from mice systemically treated with teriparatide.
    2 context sentences
    Summary · context
    Bone marrow cells from 7 days 40 microg/kg of teriparatide treated or saline control mice were cultured and Osx and osteoblast phenotypic gene expression assessed by real-time RT-PCR in these cells.
    Summary · context
    Fractured animals injected daily with either saline or 40 microg/kg of teriparatide for up to 21 days were X-rayed and histological assessment performed, as well as immunohistochemical analyses of the Osx expression in the fracture callus.
  5. 05LabEx vivo tissueMechanism

    In mice, marrow MSCs from teriparatide-treated animals matured into osteoblasts faster than saline controls.

    In plain wordsIn lab tests, marrow cells from teriparatide-treated mice matured into bone-forming cells faster than cells from saline-treated mice.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseOsteoblast maturation
    Study

    mousen: not reported in source

    Cultured marrow-derived MSCs from teriparatide- or saline-treated mice
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 microg/kg · injection · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, these MSCs undergo accelerated osteoblast maturation compared to saline injected controls.
    2 context sentences
    Summary · context
    Bone marrow cells from 7 days 40 microg/kg of teriparatide treated or saline control mice were cultured and Osx and osteoblast phenotypic gene expression assessed by real-time RT-PCR in these cells.
    Summary · context
    Fractured animals injected daily with either saline or 40 microg/kg of teriparatide for up to 21 days were X-rayed and histological assessment performed, as well as immunohistochemical analyses of the Osx expression in the fracture callus.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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