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Study · Randomized controlled trial · n = 93 · 2005

4 results

Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin.

Robinson LR, Fitzgerald NC, Doughty DG, Dawes NC, Berge CA, Bissett DL

International journal of cosmetic science1 Jun 2005Cited by 104 (Europe PMC)

PMID18492182 (opens in a new tab)DOI10.1111/j.1467-2494.2005.00261.x (opens in a new tab)PepBankPUB-18492182
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialSafety outcome

    In women with photoaged facial skin, topical pal-KTTKS was well tolerated.

    In plain wordsIn women with photoaged facial skin, topical pal-KTTKS was well tolerated.

    Peptide
    Matrixyl (palmitoyl pentapeptide-4)
    Outcome
    Not applicableSkin tolerability
    Study

    n = 93

    Outcome group
    Adverse events · Skin and wound
    Studied dose
    3 ppm · topical · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    Pal-KTTKS was well tolerated by the skin
    1 context sentence
    Summary · context
    Caucasian female subjects (n = 93, aged 35-55) participated in a 12-week, double-blind, placebo-controlled, split-face, left-right randomized clinical study assessing two topical products: moisturizer control product vs. the same moisturizer product containing 3 ppm pal-KTTKS.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women with photoaged facial skin, a moisturizer with 3 ppm pal-KTTKS improved wrinkles and fine lines versus the same moisturizer alone by both quantitative technical and expert grader image analysis.

    In plain wordsIn women with photoaged facial skin, a moisturizer with pal-KTTKS improved wrinkles and fine lines more than the same moisturizer without it.

    Peptide
    Matrixyl (palmitoyl pentapeptide-4)
    Outcome
    DecreaseWrinkles and fine lines by technical and expert grader image analysis
    Study

    n = 93

    Comparator
    Same moisturizer without pal-KTTKS
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    3 ppm · topical · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    Pal-KTTKS was well tolerated by the skin and provided significant improvement vs. placebo control for reduction in wrinkles/fine lines by both quantitative technical and expert grader image analysis.
    1 context sentence
    Summary · context
    Caucasian female subjects (n = 93, aged 35-55) participated in a 12-week, double-blind, placebo-controlled, split-face, left-right randomized clinical study assessing two topical products: moisturizer control product vs. the same moisturizer product containing 3 ppm pal-KTTKS.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In women, pal-KTTKS reduced wrinkles and fine lines versus placebo moisturizer by expert grader image analysis.

    In plain wordsIn women, pal-KTTKS reduced wrinkles and fine lines more than placebo moisturizer in expert image ratings.

    Peptide
    Matrixyl (palmitoyl pentapeptide-4)
    Outcome
    DecreaseWrinkles and fine lines by expert grading
    Study

    n = 93

    Comparator
    Same moisturizer without pal-KTTKS
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    3 ppm · topical · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    Pal-KTTKS was well tolerated by the skin and provided significant improvement vs. placebo control for reduction in wrinkles/fine lines by both quantitative technical and expert grader image analysis.
    1 context sentence
    Summary · context
    Caucasian female subjects (n = 93, aged 35-55) participated in a 12-week, double-blind, placebo-controlled, split-face, left-right randomized clinical study assessing two topical products: moisturizer control product vs. the same moisturizer product containing 3 ppm pal-KTTKS.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In women, self-assessments reported significant fine line and wrinkle improvements with pal-KTTKS.

    In plain wordsIn women, self-assessments reported improved fine lines and wrinkles with pal-KTTKS.

    Peptide
    Matrixyl (palmitoyl pentapeptide-4)
    Outcome
    DecreaseSelf-assessed fine lines and wrinkles
    Study

    n = 93

    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    3 ppm · topical · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    In self-assessments, subjects also reported significant fine line/wrinkle improvements and noted directional effects for other facial improvement parameters.
    1 context sentence
    Summary · context
    Caucasian female subjects (n = 93, aged 35-55) participated in a 12-week, double-blind, placebo-controlled, split-face, left-right randomized clinical study assessing two topical products: moisturizer control product vs. the same moisturizer product containing 3 ppm pal-KTTKS.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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