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Study · Animal study (in vivo) · rat · 2008

5 results

[Compensatory effect of selank on the mnestic functions disturbed by neurotoxic damage of the noradrenergic system of the rat brain].

Kozlovskiĭ II, Belozertsev IuF, Semenova TP, Zuĭkov AV, Kozlovskaia MM

Eksperimental'naia i klinicheskaia farmakologiia1 Mar 2008

PMID18488898 (opens in a new tab)PepBankPUB-18488898
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats with noradrenergic system damage from disulfiram, selank recovered impaired learning and memory.

    In plain wordsIn rats with noradrenaline-system damage from disulfiram, selank restored learning and memory.

    Peptide
    Selank
    Outcome
    IncreaseLearning and memory after disulfiram-induced noradrenergic damage
    Study

    ratn: not reported in source

    Wistar rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It has been shown that the peptide anxiolytic drug Selank recovers learning and memory impaired by damage of the noradrenergic (NA) brain system in Wistar rats after injection of the NA-synthesis inhibitor disulfiram, administration of neurotoxic compound 6-OHDA, or a combined induction of hypoxic h…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats with noradrenergic system damage from 6-OHDA, selank recovered impaired learning and memory.

    In plain wordsIn rats with noradrenaline-system damage from 6-OHDA, selank restored learning and memory.

    Peptide
    Selank
    Outcome
    IncreaseLearning and memory after 6-OHDA-induced noradrenergic damage
    Study

    ratn: not reported in source

    Wistar rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It has been shown that the peptide anxiolytic drug Selank recovers learning and memory impaired by damage of the noradrenergic (NA) brain system in Wistar rats after injection of the NA-synthesis inhibitor disulfiram, administration of neurotoxic compound 6-OHDA, or a combined induction of hypoxic h…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats with combined hypoxic hypoxia and hypercapnia, selank recovered impaired learning and memory.

    In plain wordsIn rats exposed to low oxygen and high carbon dioxide, selank restored learning and memory.

    Peptide
    Selank
    Outcome
    IncreaseLearning and memory after hypoxic hypoxia and hypercapnia
    Study

    ratn: not reported in source

    Wistar rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It has been shown that the peptide anxiolytic drug Selank recovers learning and memory impaired by damage of the noradrenergic (NA) brain system in Wistar rats after injection of the NA-synthesis inhibitor disulfiram, administration of neurotoxic compound 6-OHDA, or a combined induction of hypoxic h…
  4. 04AnimalAnimal study (in vivo)Mechanism

    In Wistar rats with noradrenergic system damage, the main component of selank action was stimulation of the search reflex in the first trials of the learning session.

    In plain wordsIn rats with noradrenaline-system damage, selank mainly acted by stimulating the search reflex in the first learning trials.

    Peptide
    Selank
    Outcome
    IncreaseSearch reflex in first trials of learning
    Study

    ratn: not reported in source

    Wistar rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The main component of the Selank action is the stimulation of the search reflex aimed to distinguish an adequate adaptive response in the first trials of the learning session.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats with noradrenergic system damage, selank enhanced memory consolidation and retrieval.

    In plain wordsIn rats with noradrenaline-system damage, selank improved how memories were stored and recalled.

    Peptide
    Selank
    Outcome
    IncreaseMemory consolidation and retrieval
    Study

    ratn: not reported in source

    Wistar rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The enhancement of memory consolidation and retrieval shows evidence for stimulation of the brain motivation mechanisms impaired by the NA system damage.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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