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Study · Animal study (in vivo) · mouse · 2008

5 results

Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice.

Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR

Molecular endocrinology (Baltimore, Md.)1 May 2008Cited by 195 (Europe PMC)

PMID18451093 (opens in a new tab)PMCIDPMC2453606 (opens in a new tab)DOI10.1210/me.2008-0067 (opens in a new tab)PepBankPUB-18451093
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Sim1 haploinsufficient mice, centrally given oxytocin decreased food intake at a dose that did not affect wild-type mice.

    In plain wordsIn mice with one working copy of Sim1, oxytocin given into the brain reduced food intake at a dose that did not affect normal mice.

    Peptide
    Oxytocin
    Outcome
    DecreaseFood intake after central oxytocin
    Study

    mousen: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · central administrationAs given in this study (mouse).

    Source sentences

    Summary
    Oxt decreased the food intake and weight gain of Sim1(+/-) mice at a dose that did not affect wild-type mice.
    1 context sentence
    Summary · context
    To test whether Oxt itself regulates feeding, we measured the effects of central administration of an Oxt receptor antagonist or repeated doses of Oxt on food intake of Sim1(+/-) and wild-type mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Sim1 haploinsufficient mice, centrally given oxytocin decreased weight gain at a dose that did not affect wild-type mice.

    In plain wordsIn mice with one working copy of Sim1, oxytocin given into the brain reduced weight gain at a dose that did not affect normal mice.

    Peptide
    Oxytocin
    Outcome
    DecreaseWeight gain after central oxytocin
    Study

    mousen: not reported in source

    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · central administrationAs given in this study (mouse).

    Source sentences

    Summary
    Oxt decreased the food intake and weight gain of Sim1(+/-) mice at a dose that did not affect wild-type mice.
    1 context sentence
    Summary · context
    To test whether Oxt itself regulates feeding, we measured the effects of central administration of an Oxt receptor antagonist or repeated doses of Oxt on food intake of Sim1(+/-) and wild-type mice.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In Sim1 haploinsufficient mice, hypothalamic mRNA for the body's own oxytocin was decreased by 80% compared with wild-type mice.

    In plain wordsIn mice with one working copy of the Sim1 gene, the body's own oxytocin messenger RNA was 80% lower than in normal mice.

    Peptide
    Oxytocin
    Outcome
    DecreaseHypothalamic Oxt mRNA
    Study

    mousen: not reported in source

    Comparator
    Wild-type mice
    Outcome group
    Appetite and food intake · Endocrine and hormones

    Measurements

    Oxt mRNA decrease
    80%
    Sim1(+/-) mice

    Source sentences

    Summary
    Oxt mRNA and peptide were decreased by 80% in Sim1(+/-) mice, whereas TRH, CRH, arginine vasopressin (Avp), and somatostatin mRNAs were decreased by 20-40%.
    1 context sentence
    Summary · context
    To test this hypothesis, we measured hypothalamic expression of PVN neuropeptides in Sim1(+/-) and wild-type mice.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In Sim1 haploinsufficient mice, hypothalamic levels of the body's own oxytocin peptide were decreased by 80% compared with wild-type mice.

    In plain wordsIn mice with one working copy of the Sim1 gene, the body's own oxytocin peptide was 80% lower than in normal mice.

    Peptide
    Oxytocin
    Outcome
    DecreaseHypothalamic oxytocin peptide
    Study

    mousen: not reported in source

    Comparator
    Wild-type mice
    Outcome group
    Appetite and food intake · Endocrine and hormones

    Measurements

    Oxt peptide decrease
    80%
    Sim1(+/-) mice

    Source sentences

    Summary
    Oxt mRNA and peptide were decreased by 80% in Sim1(+/-) mice, whereas TRH, CRH, arginine vasopressin (Avp), and somatostatin mRNAs were decreased by 20-40%.
    1 context sentence
    Summary · context
    To test this hypothesis, we measured hypothalamic expression of PVN neuropeptides in Sim1(+/-) and wild-type mice.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 05AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In Sim1 haploinsufficient mice, the body's own Oxt mRNA, but not CRH mRNA, responded abnormally to feeding state.

    In plain wordsIn mice with one working copy of the Sim1 gene, the body's own oxytocin messenger RNA responded abnormally to feeding state.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxt mRNA regulation by feeding state
    Study

    mousen: not reported in source

    Comparator
    Wild-type mice
    Outcome group
    Appetite and food intake · Endocrine and hormones

    Source sentences

    Summary
    Sim1(+/-) mice also showed abnormal regulation of Oxt but not CRH mRNA in response to feeding state.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:04 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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