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Study · In vitro (cells) · 2008

5 results

Vasoactive intestinal peptide protects against beta-amyloid-induced neurodegeneration by inhibiting microglia activation at multiple levels.

Delgado M, Varela N, Gonzalez-Rey E

Glia1 Aug 2008Cited by 66 (Europe PMC)

PMID18442091 (opens in a new tab)DOI10.1002/glia.20681 (opens in a new tab)PepBankPUB-18442091
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cell models, VIP inhibited beta-amyloid-induced neurodegeneration by indirectly inhibiting the production of inflammatory and neurotoxic agents by activated microglia.

    In plain wordsIn cells, VIP reduced nerve cell damage caused by beta-amyloid, by calming inflammatory immune cells in the brain.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseAbeta-induced neurodegeneration
    Study

    n: not reported in source

    Abeta-activated microglia cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we report that VIP inhibits Abeta-induced neurodegeneration by indirectly inhibiting the production of a wide panel of inflammatory and neurotoxic agents by activated microglia cells.
  2. 02LabIn vitro (cells)Efficacy outcome

    In Abeta-activated microglia cells, VIP inhibited the production of a wide panel of inflammatory and neurotoxic agents.

    In plain wordsIn cells, VIP lowered the release of many inflammatory and harmful substances from activated brain immune cells.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseInflammatory and neurotoxic agents from activated microglia
    Study

    n: not reported in source

    Abeta-activated microglia cells
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    indirectly inhibiting the production of a wide panel of inflammatory and neurotoxic agents by activated microglia cells.
  3. 03LabIn vitro (cells)Mechanism

    In Abeta-activated microglia cells, the inhibitory effect of VIP was mediated by blocking signaling through the p38 MAPK cascade.

    In plain wordsIn cells, VIP worked partly by blocking the p38 MAPK signaling route.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Decreasep38 MAPK signaling
    Study

    n: not reported in source

    Abeta-activated microglia cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The inhibitory effect of VIP is mediated by blocking signaling through the p38 MAPK, p42/p44 MAPK, and NFkB cascades, the three major transduction pathways involved in the transcription of inflammatory mediators and the production of free radicals by Abeta-activated microglia cells.
  4. 04LabIn vitro (cells)Mechanism

    In Abeta-activated microglia cells, the inhibitory effect of VIP was mediated by blocking signaling through the p42/p44 MAPK cascade.

    In plain wordsIn cells, VIP worked partly by blocking the p42/p44 MAPK signaling route.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Decreasep42/p44 MAPK signaling
    Study

    n: not reported in source

    Abeta-activated microglia cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The inhibitory effect of VIP is mediated by blocking signaling through the p38 MAPK, p42/p44 MAPK, and NFkB cascades, the three major transduction pathways involved in the transcription of inflammatory mediators and the production of free radicals by Abeta-activated microglia cells.
  5. 05LabIn vitro (cells)Mechanism

    In Abeta-activated microglia cells, the inhibitory effect of VIP was mediated by blocking signaling through the NFkB cascade.

    In plain wordsIn cells, VIP worked partly by blocking the NFkB signaling route.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseNFkB signaling
    Study

    n: not reported in source

    Abeta-activated microglia cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The inhibitory effect of VIP is mediated by blocking signaling through the p38 MAPK, p42/p44 MAPK, and NFkB cascades, the three major transduction pathways involved in the transcription of inflammatory mediators and the production of free radicals by Abeta-activated microglia cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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