Skip to content

Study · In vitro (cells) · rat · 2008

5 results

Effects of behaviorally active ACTH (4-10) analogue - Semax on rat basal forebrain cholinergic neurons.

Grivennikov IA, Dolotov OV, Zolotarev YA, Andreeva LA, Myasoedov NF, Leacher L, Black IB, Dreyfus CF

Restorative neurology and neuroscience1 Jan 2008Cited by 6 (Europe PMC)

PMID18431004 (opens in a new tab)DOI10.3233/rnn-2008-00419 (opens in a new tab)PepBankPUB-18431004
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In primary rat basal forebrain cultures, Semax increased survival of cholinergic neurons by approximately 1.5 to 1.7 fold.

    In plain wordsIn cells from rat brain, Semax raised the survival of cholinergic neurons by about 1.5 to 1.7 times.

    Peptide
    Semax
    Outcome
    IncreaseSurvival of cholinergic basal forebrain neurons
    Study

    ratn: not reported in source

    Primary neuronal and glial cultures from basal forebrain
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Survival increase
    1.5 to 1.7 fold
    cholinergic basal forebrain neurons

    Source sentences

    Summary
    We have shown that Semax may approximately 1.5-1.7 fold increase survival of cholinergic basal forebrain neurons in vitro.
    2 context sentences
    Summary · context
    We studied the effect of Semax (Met-Glu-His-Phe-Pro-Gly-Pro), a behaviorally active adrenocorticotropic hormone (4-10) analogue, on survival of cholinergic basal forebrain neurons in vitro.
    Summary · context
    Primary cultures of neuronal and glial cells from basal forebrain of rats were used in all experiments.
  2. 02LabIn vitro (cells)Mechanism

    In dissociated rat basal forebrain tissue cultures, Semax at 100 nM stimulated choline acetyltransferase activity.

    In plain wordsIn cells from rat brain, Semax raised the activity of an enzyme (choline acetyltransferase) that cholinergic neurons need.

    Peptide
    Semax
    Outcome
    IncreaseCholine acetyltransferase activity
    Study

    ratn: not reported in source

    Primary neuronal and glial cultures from basal forebrain
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 nMAs given in this study (rat).

    Source sentences

    Summary
    Moreover, Semax (100 nM) stimulated activity of choline acetyltransferase in dissociated basal forebrain tissue cultures.
    2 context sentences
    Summary · context
    We studied the effect of Semax (Met-Glu-His-Phe-Pro-Gly-Pro), a behaviorally active adrenocorticotropic hormone (4-10) analogue, on survival of cholinergic basal forebrain neurons in vitro.
    Summary · context
    Primary cultures of neuronal and glial cells from basal forebrain of rats were used in all experiments.
  3. 03LabIn vitro (cells)Efficacy outcome

    In primary rat basal forebrain cultures, Semax did not affect the number of GABA-ergic neurons.

    In plain wordsIn cells from rat brain, Semax did not change the number of GABA-ergic neurons.

    Peptide
    Semax
    Outcome
    No significant changeNumber of GABA-ergic neurons
    Study

    ratn: not reported in source

    Primary neuronal and glial cultures from basal forebrain
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, the numbers of GABA-ergic neurons, total neuron specific enolase neurons were not affected.
    2 context sentences
    Summary · context
    We studied the effect of Semax (Met-Glu-His-Phe-Pro-Gly-Pro), a behaviorally active adrenocorticotropic hormone (4-10) analogue, on survival of cholinergic basal forebrain neurons in vitro.
    Summary · context
    Primary cultures of neuronal and glial cells from basal forebrain of rats were used in all experiments.
  4. 04LabIn vitro (cells)Efficacy outcome

    In primary rat basal forebrain cultures, Semax did not affect the number of total neuron specific enolase neurons.

    In plain wordsIn cells from rat brain, Semax did not change the total number of neurons.

    Peptide
    Semax
    Outcome
    No significant changeNumber of total neuron specific enolase neurons
    Study

    ratn: not reported in source

    Primary neuronal and glial cultures from basal forebrain
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, the numbers of GABA-ergic neurons, total neuron specific enolase neurons were not affected.
    2 context sentences
    Summary · context
    We studied the effect of Semax (Met-Glu-His-Phe-Pro-Gly-Pro), a behaviorally active adrenocorticotropic hormone (4-10) analogue, on survival of cholinergic basal forebrain neurons in vitro.
    Summary · context
    Primary cultures of neuronal and glial cells from basal forebrain of rats were used in all experiments.
  5. 05LabIn vitro (cells)Efficacy outcome

    In primary rat glial cultures, Semax at 1 nM to 10 microM did not affect proliferation of glial cells.

    In plain wordsIn cells from rat brain, Semax did not change glial cell growth at the tested concentrations.

    Peptide
    Semax
    Outcome
    No significant changeGlial cell proliferation
    Study

    ratn: not reported in source

    Primary neuronal and glial cultures from basal forebrain
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 nM to 10 microMAs given in this study (rat).

    Source sentences

    Summary
    In concentration from 1 nM to 10 microM, Semax did not affect proliferation of glial cells in primary cultures.
    2 context sentences
    Summary · context
    We studied the effect of Semax (Met-Glu-His-Phe-Pro-Gly-Pro), a behaviorally active adrenocorticotropic hormone (4-10) analogue, on survival of cholinergic basal forebrain neurons in vitro.
    Summary · context
    Primary cultures of neuronal and glial cells from basal forebrain of rats were used in all experiments.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.