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Study · Animal study (in vivo) · rat · 2007

6 results

[Delta-sleep inducing peptide and the drug deltaran: possible approaches to antistress protection].

Koplik EV, Umriukhin PE, Konorova IL, Terekhina OL, Mikhaleva II, Gannushkina IV, Sudakov KV

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2007Cited by 1 (Europe PMC)

PMID18427460 (opens in a new tab)PepBankPUB-18427460
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, the delta-sleep inducing peptide amplified burst activity of most recorded neurons in the dorsal hippocampus, hypothalamic paraventricular nucleus and ventral anterior thalamic nucleus.

    In plain wordsIn rats, the peptide raised the firing of most recorded neurons in three brain areas.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseBurst activity of neurons (hippocampus, hypothalamus, thalamus)
    Study

    ratn: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · microiontophoresisAs given in this study (rat).

    Source sentences

    Summary
    Deltaran and the delta-sleep inducing peptide exert in general similar effect on the burst activity of neurons in the dorsal hippocampus, hypothalamic paraventricular nucleus and ventral anterior thalamic nucleus, inducing amplification of the majority of recorded units.
    2 context sentences
    Summary · context
    The activation of neuronal activity was seen mostly after the delta-sleep inducing peptide microiontophoresis in the dorsal hippocampus and after the deltaran application in the hypothalamic paraventricular nuclei.
    Summary · context
    An aim of the present study was a comparative investigation of a delta-sleep inducing peptide and the drug deltaran on the neural activity of the brain structures involved in emotional processing.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, neuronal activation was seen mostly after microiontophoresis of the delta-sleep inducing peptide in the dorsal hippocampus.

    In plain wordsIn rats, the peptide activated neurons most strongly in the hippocampus.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseNeuronal activation in dorsal hippocampus
    Study

    ratn: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · microiontophoresisAs given in this study (rat).

    Source sentences

    Summary
    The activation of neuronal activity was seen mostly after the delta-sleep inducing peptide microiontophoresis in the dorsal hippocampus and after the deltaran application in the hypothalamic paraventricular nuclei.
    1 context sentence
    Summary · context
    An aim of the present study was a comparative investigation of a delta-sleep inducing peptide and the drug deltaran on the neural activity of the brain structures involved in emotional processing.

Studies that did not test the peptide alone4

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Mechanism

    In rats, Deltaran (a DSIP preparation) amplified burst activity of most recorded neurons in the dorsal hippocampus, hypothalamic paraventricular nucleus and ventral anterior thalamic nucleus.

    In plain wordsIn rats, the DSIP preparation Deltaran raised the firing of most recorded neurons in three brain areas.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseBurst activity of neurons (hippocampus, hypothalamus, thalamus)
    Study

    ratn: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition

    Source sentences

    Summary
    Deltaran and the delta-sleep inducing peptide exert in general similar effect on the burst activity of neurons in the dorsal hippocampus, hypothalamic paraventricular nucleus and ventral anterior thalamic nucleus, inducing amplification of the majority of recorded units.
    1 context sentence
    Summary · context
    An aim of the present study was a comparative investigation of a delta-sleep inducing peptide and the drug deltaran on the neural activity of the brain structures involved in emotional processing.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 04AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Mechanism

    In rats, neuronal activation was seen mostly after Deltaran (a DSIP preparation) application in the hypothalamic paraventricular nuclei.

    In plain wordsIn rats, the DSIP preparation Deltaran activated neurons most strongly in the hypothalamic paraventricular nucleus.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseNeuronal activation in hypothalamic paraventricular nucleus
    Study

    ratn: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition

    Source sentences

    Summary
    The activation of neuronal activity was seen mostly after the delta-sleep inducing peptide microiontophoresis in the dorsal hippocampus and after the deltaran application in the hypothalamic paraventricular nuclei.
    1 context sentence
    Summary · context
    An aim of the present study was a comparative investigation of a delta-sleep inducing peptide and the drug deltaran on the neural activity of the brain structures involved in emotional processing.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  3. 05AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In rats, the index characterizing blood supply was significantly higher in all rats receiving Deltaran (a DSIP preparation) than in controls.

    In plain wordsIn rats, the DSIP preparation Deltaran gave a higher blood supply index than in controls.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseIndex of blood supply
    Study

    ratn: not reported in source

    Comparator
    Controls
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The index characterizing blood supply was significantly higher in all rats receiving deltaran as compared to the controls.
    1 context sentence
    Summary · context
    An aim of the present study was a comparative investigation of a delta-sleep inducing peptide and the drug deltaran on the neural activity of the brain structures involved in emotional processing.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  4. 06AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In rats with experimental brain ischemia, 100% of animals receiving Deltaran (a DSIP preparation) survived versus 38% of those not exposed to it.

    In plain wordsIn rats with brain ischemia, more survived with the DSIP preparation Deltaran than without it.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSurvival of experimental brain ischemia
    Study

    ratn: not reported in source

    Comparator
    Animals not exposed to Deltaran
    Outcome group
    Neuroprotection · Nervous system and cognition

    Measurements

    Survival, Deltaran
    100%
    Deltaran group
    Survival, no Deltaran
    38%
    animals not exposed to Deltaran

    Source sentences

    Summary
    Animals receiving deltaran survived experimental brain ischemia in 100% cases versus 38% in those not exposed to this drug.
    1 context sentence
    Summary · context
    An aim of the present study was a comparative investigation of a delta-sleep inducing peptide and the drug deltaran on the neural activity of the brain structures involved in emotional processing.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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