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Study · Animal study (in vivo) · mouse and rat · 2008

3 results

A circulating ghrelin mimetic attenuates light-induced phase delay of mice and light-induced Fos expression in the suprachiasmatic nucleus of rats.

Yi CX, Challet E, Pévet P, Kalsbeek A, Escobar C, Buijs RM

The European journal of neuroscience10 Apr 2008Cited by 40 (Europe PMC)

PMID18412617 (opens in a new tab)DOI10.1111/j.1460-9568.2008.06181.x (opens in a new tab)PepBankPUB-18412617
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, intravenous GHRP‑6 reduced light-induced SCN Fos expression at ZT13 by 50%.

    In plain wordsIn rats, intravenous GHRP‑6 reduced light-induced brain Fos expression by 50%.

    Peptide
    GHRP-6
    Outcome
    DecreaseLight-induced SCN Fos expression
    Study

    ratn: not reported in source

    Light-exposed rat suprachiasmatic nucleus
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Measurements

    Fos expression reduction
    50%
    rat SCN at ZT13

    Source sentences

    Summary
    In the present study we show that i.v. administration of GHRP-6 decreases light-induced Fos expression at ZT13 in the rat SCN by 50%, indicating that light-induced changes in the SCN Fos expression can also be reduced by GHRP-6.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, peripheral GHRP‑6 attenuated light-induced phase delays at ZT13 by 45%.

    In plain wordsIn mice, peripheral GHRP‑6 reduced light-induced delays in circadian timing by 45%.

    Peptide
    GHRP-6
    Outcome
    DecreaseLight-induced phase delay
    Study

    mousen: not reported in source

    Light-induced circadian phase shifts
    Outcome group
    Sleep · Nervous system and cognition
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (mouse).

    Measurements

    Phase delay attenuation
    45%
    mice at ZT13

    Source sentences

    Summary
    Because it is difficult to study light-induced phase changes in rats, we examined the functional effects of GHRP-6 on light-induced phase shifts in mice and demonstrated that peripherally injected GHRP-6 attenuates light-induced phase delays at ZT13 by 45%.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, GHRP‑6 did not block light-induced SCN Fos expression.

    In plain wordsIn mice, GHRP‑6 did not block light-induced brain Fos expression.

    Peptide
    GHRP-6
    Outcome
    No significant changeLight-induced SCN Fos expression
    Study

    mousen: not reported in source

    Light-exposed mouse suprachiasmatic nucleus
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, light-induced Fos expression in the mice SCN was not blocked by GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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