Characterization of a rabbit antihuman mechano growth factor (MGF) polyclonal antibody against the last 24 amino acids of the E domain.

Philippou A, Stavropoulou A, Sourla A, Pissimissis N, Halapas A, Maridaki M, Koutsilieris M

In vivo (Athens, Greece)1 Jan 2008Cited by 21 (Europe PMC)

PMID18396778PepBankPUB-18396778

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

01LabNot a test of MGF / PEG-MGF aloneEx vivo tissueActivity measurement
The rabbit anti-MGF antiserum recognized the MGF E-peptide and not the mature IGF-1 peptide.
In plain wordsIn lab tests, an antibody was found that detects MGF and not mature IGF-1.
Peptide
MGF / PEG-MGF
Outcome
Not applicableSpecificity of rabbit anti-MGF antiserum
Study
rabbitn: not reported in source
Western blotting and immunohistochemistry with anti-MGF antiserum
Outcome group
Receptor activity and mechanism · Musculoskeletal
Source sentences
Summary
The anti-MGF antiserum was found to recognize the MGF E-peptide and not the common part of the IGF-1 isoforms, i.e. the mature IGF-1 peptide.
1 context sentence(design, population, supporting numbers)
Summary · context
New-Zealand rabbits were immunized by injections of a purified synthetic peptide corresponding to the last 24 amino acids of the human C-terminal of the MGF E domain.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-1839677801
02LabNot a test of MGF / PEG-MGF aloneEx vivo tissueActivity measurement
The anti-MGF antibody bound MGF protein in human skeletal muscle and rat cardiac muscle, and detected MGF in human muscle and in rat cardiomyocytes and smooth muscle cells.
In plain wordsIn lab tests, the antibody detected MGF in human muscle and in rat heart muscle cells and vessel wall cells.
Peptide
MGF / PEG-MGF
Outcome
Not applicableDetection of MGF in human and rat muscle tissue by anti-MGF antibody
Study
human, ratn: not reported in source
Human skeletal muscle and rat cardiac muscle tissue
Outcome group
Receptor activity and mechanism · Musculoskeletal
Source sentences
Summary
Furthermore, it specifically bound to the MGF protein in human skeletal and in rat cardiac muscle, apparently due to the considerable homology between the human and rat MGF E-peptide sequences. Immunostaining analysis showed that this polyclonal anti-MGF antibody was able to detect MGF in human musc…
1 context sentence(design, population, supporting numbers)
Summary · context
New-Zealand rabbits were immunized by injections of a purified synthetic peptide corresponding to the last 24 amino acids of the human C-terminal of the MGF E domain.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-1839677802

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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