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Study · In vitro (cells) · 2008

1 result

Mitogenic effect of the insulin analogue glargine in malignant cells in comparison with insulin and IGF-I.

Liefvendahl E, Arnqvist HJ

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme7 Apr 2008Cited by 42 (Europe PMC)

PMID18393172 (opens in a new tab)DOI10.1055/s-2008-1062739 (opens in a new tab)PepBankPUB-18393172
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In MCF-7 breast cancer cells, mitogenic sensitivity to des(1‑3)IGF-I exceeded sensitivity to IGF-I.

    In plain wordsIn cells, MCF-7 breast cancer cells responded more strongly to des(1‑3)IGF-I than to IGF-I in a DNA synthesis test.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseMitogenic sensitivity
    Study

    humann: not reported in source

    MCF-7 breast cancer cells
    Comparator
    IGF-I
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MCF-7 cells were more sensitive to des(1-3)IGF-I than to IGF-I.
    2 context sentences
    Summary · context
    The breast cancer cell lines MCF-7 and SKBR-3, and the osteosarcoma cell line SaOS-2 were used.
    Summary · context
    Mitogenic effect was determined as (3)H-thymidine incorporation into DNA.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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