Intratrabecular tunneling increases trabecular number throughout the skeleton of ovariectomized rhesus monkeys treated with parathyroid hormone 1-84.

Miller MA, Bare SP, Recker RR, Smith SY, Fox J

Bone29 Feb 2008Cited by 17 (Europe PMC)

PMID18387869DOI10.1016/j.bone.2008.01.029PepBankPUB-18387869

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rhesus monkeys, PTH(1-84) increased L3 tunneling frequency to 0.27/mm(2) at 5 microg/kg versus approximately 0.05/mm(2) in controls.
In plain wordsIn rhesus monkeys, PTH at 5 microg/kg increased vertebral tunneling frequency versus controls.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseL3 tunneling frequency at 5 microg/kg
Study
rhesus monkeysn: not reported in source
Ovariectomized adult rhesus monkeys
Comparator
Sham and ovariectomized controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
5 microg/kg daily · 16 monthsAs given in this study (rhesus monkeys).
Source sentences
Summary
At L3, tunneling frequency was low in control sham and OVX animals ( approximately 0.05/mm(2)) but increased significantly in PTH(1-84)-treated animals (0.27, 0.49 and 0.95/mm(2) with the 5, 10 and 25 microg/kg doses, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
Daily treatment of ovariectomized (OVX) adult rhesus monkeys with human parathyroid hormone (PTH) 1-84 for 16 months increases trabecular bone volume (BV/TV), number (Tb.N) and connectivity at lumbar vertebra-3 (L3) and thoracic vertebra-10.
Summary · context
Using histomorphometry to determine frequency of events, we have now quantified intratrabecular tunneling at L3 and extended it to investigate the effects of PTH(1-84) treatment on trabecular bone at the proximal femur, distal radius and iliac crest of these animals.
Report a problemFND-1838786901
02AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rhesus monkeys, PTH(1-84) increased L3 tunneling frequency to 0.49/mm(2) at 10 microg/kg versus approximately 0.05/mm(2) in controls.
In plain wordsIn rhesus monkeys, PTH at 10 microg/kg increased vertebral tunneling frequency versus controls.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseL3 tunneling frequency at 10 microg/kg
Study
rhesus monkeysn: not reported in source
Ovariectomized adult rhesus monkeys
Comparator
Sham and ovariectomized controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg daily · 16 monthsAs given in this study (rhesus monkeys).
Source sentences
Summary
At L3, tunneling frequency was low in control sham and OVX animals ( approximately 0.05/mm(2)) but increased significantly in PTH(1-84)-treated animals (0.27, 0.49 and 0.95/mm(2) with the 5, 10 and 25 microg/kg doses, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
Daily treatment of ovariectomized (OVX) adult rhesus monkeys with human parathyroid hormone (PTH) 1-84 for 16 months increases trabecular bone volume (BV/TV), number (Tb.N) and connectivity at lumbar vertebra-3 (L3) and thoracic vertebra-10.
Summary · context
Using histomorphometry to determine frequency of events, we have now quantified intratrabecular tunneling at L3 and extended it to investigate the effects of PTH(1-84) treatment on trabecular bone at the proximal femur, distal radius and iliac crest of these animals.
Report a problemFND-1838786902
03AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rhesus monkeys, PTH(1-84) increased L3 tunneling frequency to 0.95/mm(2) at 25 microg/kg versus approximately 0.05/mm(2) in controls.
In plain wordsIn rhesus monkeys, PTH at 25 microg/kg increased vertebral tunneling frequency versus controls.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseL3 tunneling frequency at 25 microg/kg
Study
rhesus monkeysn: not reported in source
Ovariectomized adult rhesus monkeys
Comparator
Sham and ovariectomized controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
25 microg/kg daily · 16 monthsAs given in this study (rhesus monkeys).
Source sentences
Summary
At L3, tunneling frequency was low in control sham and OVX animals ( approximately 0.05/mm(2)) but increased significantly in PTH(1-84)-treated animals (0.27, 0.49 and 0.95/mm(2) with the 5, 10 and 25 microg/kg doses, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
Daily treatment of ovariectomized (OVX) adult rhesus monkeys with human parathyroid hormone (PTH) 1-84 for 16 months increases trabecular bone volume (BV/TV), number (Tb.N) and connectivity at lumbar vertebra-3 (L3) and thoracic vertebra-10.
Summary · context
Using histomorphometry to determine frequency of events, we have now quantified intratrabecular tunneling at L3 and extended it to investigate the effects of PTH(1-84) treatment on trabecular bone at the proximal femur, distal radius and iliac crest of these animals.
Report a problemFND-1838786903
04AnimalAnimal study (in vivo)Efficacy outcome
In rhesus monkeys, tunneling frequencies were similar across skeletal sites within all groups, including PTH(1-84) groups.
In plain wordsIn rhesus monkeys, tunneling frequencies were similar across skeletal sites in all groups, including PTH groups.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
No significant changeTunneling frequencies across skeletal sites
Study
rhesus monkeysn: not reported in source
Ovariectomized adult rhesus monkeys
Comparator
Other skeletal sites in the same group
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 16 monthsAs given in this study (rhesus monkeys).
Source sentences
Summary
Very similar tunneling frequencies were observed at all skeletal sites in all groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Daily treatment of ovariectomized (OVX) adult rhesus monkeys with human parathyroid hormone (PTH) 1-84 for 16 months increases trabecular bone volume (BV/TV), number (Tb.N) and connectivity at lumbar vertebra-3 (L3) and thoracic vertebra-10.
Summary · context
Using histomorphometry to determine frequency of events, we have now quantified intratrabecular tunneling at L3 and extended it to investigate the effects of PTH(1-84) treatment on trabecular bone at the proximal femur, distal radius and iliac crest of these animals.
Report a problemFND-1838786904
05AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rhesus monkeys, PTH(1-84) increased iliac crest tunnels with significant time- and dose-related responses.
In plain wordsIn rhesus monkeys, iliac crest tunnels increased during PTH treatment, with time- and dose-related responses.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseIliac crest tunnels at 6 months
Study
rhesus monkeysn: not reported in source
Ovariectomized adult rhesus monkeys
Comparator
Baseline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 6 monthsAs given in this study (rhesus monkeys).
Source sentences
Summary
Iliac crest biopsies were also collected at baseline and after 6 months of treatment and showed significant time- and dose-related increases in tunnels.
2 context sentences(design, population, supporting numbers)
Summary · context
Daily treatment of ovariectomized (OVX) adult rhesus monkeys with human parathyroid hormone (PTH) 1-84 for 16 months increases trabecular bone volume (BV/TV), number (Tb.N) and connectivity at lumbar vertebra-3 (L3) and thoracic vertebra-10.
Summary · context
Using histomorphometry to determine frequency of events, we have now quantified intratrabecular tunneling at L3 and extended it to investigate the effects of PTH(1-84) treatment on trabecular bone at the proximal femur, distal radius and iliac crest of these animals.
Report a problemFND-1838786905
06AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rhesus monkeys, PTH(1-84) significantly increased trabecular number at all skeletal sites.
In plain wordsIn rhesus monkeys, PTH increased trabecular number at all examined skeletal sites versus controls.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseTrabecular number across sites
Study
rhesus monkeysn: not reported in source
Ovariectomized adult rhesus monkeys
Comparator
Sham and ovariectomized controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 16 monthsAs given in this study (rhesus monkeys).
Source sentences
Summary
Although the pattern and magnitude of response varied slightly from site to site, PTH(1-84) treatment significantly increased Tb.N, as well as BV/TV and bone formation rate at all skeletal sites.
2 context sentences(design, population, supporting numbers)
Summary · context
Daily treatment of ovariectomized (OVX) adult rhesus monkeys with human parathyroid hormone (PTH) 1-84 for 16 months increases trabecular bone volume (BV/TV), number (Tb.N) and connectivity at lumbar vertebra-3 (L3) and thoracic vertebra-10.
Summary · context
Using histomorphometry to determine frequency of events, we have now quantified intratrabecular tunneling at L3 and extended it to investigate the effects of PTH(1-84) treatment on trabecular bone at the proximal femur, distal radius and iliac crest of these animals.
Report a problemFND-1838786906
07AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rhesus monkeys, PTH(1-84) significantly increased trabecular bone volume at all skeletal sites.
In plain wordsIn rhesus monkeys, PTH increased trabecular bone volume at all examined skeletal sites versus controls.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseTrabecular bone volume across sites
Study
rhesus monkeysn: not reported in source
Ovariectomized adult rhesus monkeys
Comparator
Sham and ovariectomized controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 16 monthsAs given in this study (rhesus monkeys).
Source sentences
Summary
Although the pattern and magnitude of response varied slightly from site to site, PTH(1-84) treatment significantly increased Tb.N, as well as BV/TV and bone formation rate at all skeletal sites.
2 context sentences(design, population, supporting numbers)
Summary · context
Daily treatment of ovariectomized (OVX) adult rhesus monkeys with human parathyroid hormone (PTH) 1-84 for 16 months increases trabecular bone volume (BV/TV), number (Tb.N) and connectivity at lumbar vertebra-3 (L3) and thoracic vertebra-10.
Summary · context
Using histomorphometry to determine frequency of events, we have now quantified intratrabecular tunneling at L3 and extended it to investigate the effects of PTH(1-84) treatment on trabecular bone at the proximal femur, distal radius and iliac crest of these animals.
Report a problemFND-1838786907
08AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rhesus monkeys, PTH(1-84) significantly increased bone formation rate at all skeletal sites.
In plain wordsIn rhesus monkeys, PTH increased bone formation rate at all examined skeletal sites versus controls.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseBone formation rate across sites
Study
rhesus monkeysn: not reported in source
Ovariectomized adult rhesus monkeys
Comparator
Sham and ovariectomized controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 16 monthsAs given in this study (rhesus monkeys).
Source sentences
Summary
Although the pattern and magnitude of response varied slightly from site to site, PTH(1-84) treatment significantly increased Tb.N, as well as BV/TV and bone formation rate at all skeletal sites.
2 context sentences(design, population, supporting numbers)
Summary · context
Daily treatment of ovariectomized (OVX) adult rhesus monkeys with human parathyroid hormone (PTH) 1-84 for 16 months increases trabecular bone volume (BV/TV), number (Tb.N) and connectivity at lumbar vertebra-3 (L3) and thoracic vertebra-10.
Summary · context
Using histomorphometry to determine frequency of events, we have now quantified intratrabecular tunneling at L3 and extended it to investigate the effects of PTH(1-84) treatment on trabecular bone at the proximal femur, distal radius and iliac crest of these animals.
Report a problemFND-1838786908
09AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rhesus monkeys, PTH(1-84) modestly but significantly increased trabecular thickness only at the iliac crest.
In plain wordsIn rhesus monkeys, PTH significantly increased trabecular thickness only at the iliac crest versus controls.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseTrabecular thickness at iliac crest
Study
rhesus monkeysn: not reported in source
Ovariectomized adult rhesus monkeys
Comparator
Sham and ovariectomized controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 16 monthsAs given in this study (rhesus monkeys).
Source sentences
Summary
A modest but statistically significant increase in trabecular thickness occurred only at the iliac crest.
2 context sentences(design, population, supporting numbers)
Summary · context
Daily treatment of ovariectomized (OVX) adult rhesus monkeys with human parathyroid hormone (PTH) 1-84 for 16 months increases trabecular bone volume (BV/TV), number (Tb.N) and connectivity at lumbar vertebra-3 (L3) and thoracic vertebra-10.
Summary · context
Using histomorphometry to determine frequency of events, we have now quantified intratrabecular tunneling at L3 and extended it to investigate the effects of PTH(1-84) treatment on trabecular bone at the proximal femur, distal radius and iliac crest of these animals.
Report a problemFND-1838786909

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

Subjects

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MeSH terms

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