Skip to content

Study · Ex vivo tissue · rat · 2007

3 results

[The effect of pineal peptide preparations on proliferative activity in organotypic culture of the preoptic hypothalamus area].

Miliutina IuP, Kozina LS, Arutiunian AV, Chalisova NI, Lesniak VV, Morozova PIu

Advances in gerontology = Uspekhi gerontologii1 Jan 2007

PMID18383712 (opens in a new tab)PepBankPUB-18383712
Publisher pageAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In hypothalamic explants from 3-month-old female rats, epitalon at 2 ng/ml stimulated proliferative activity.

    In plain wordsIn lab-cultured brain tissue from young female rats, epitalon increased cell growth activity.

    Peptide
    Epitalon
    Outcome
    IncreaseProliferative activity of explants from 3-month-old female rats
    Study

    ratn: not reported in source

    Organotypic culture of mediobasal preoptic area explants
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    2 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    pineal peptide preparations epitalon (2 ng/ml) and epithalamin (100 ng/ml) stimulate the development of proliferative activity of explants in 3 month and 24 months female rats
  2. 02LabEx vivo tissueEfficacy outcome

    In hypothalamic explants from 24-month-old female rats, epitalon at 2 ng/ml stimulated proliferative activity.

    In plain wordsIn lab-cultured brain tissue from old female rats, epitalon increased cell growth activity.

    Peptide
    Epitalon
    Outcome
    IncreaseProliferative activity of explants from 24-month-old female rats
    Study

    ratn: not reported in source

    Organotypic culture of mediobasal preoptic area explants
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    2 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    pineal peptide preparations epitalon (2 ng/ml) and epithalamin (100 ng/ml) stimulate the development of proliferative activity of explants in 3 month and 24 months female rats
  3. 03LabEx vivo tissueEfficacy outcome

    Epitalon had a less pronounced inducing effect on the growth zone of explants, almost the same in young and old rats.

    In plain wordsIn lab-cultured brain tissue, epitalon had a mild and almost equal growth effect in young and old rat tissue.

    Peptide
    Epitalon
    Outcome
    IncreaseGrowth zone induction in explants from young and old rats
    Study

    ratn: not reported in source

    Organotypic culture of mediobasal preoptic area explants
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    2 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    It has been shown that epithalamin is more effective in young rats in comparison with old animals, but epitalon as well as epithalamin have almost the same less pronounced inducing effect on growth zone in MPA explants from young and old animals.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.