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Study · Animal study (in vivo) · mouse · 2008

3 results

Reproductive hormones regulate the selective permeability of the blood-brain barrier.

Wilson AC, Clemente L, Liu T, Bowen RL, Meethal SV, Atwood CS

Biochimica et biophysica acta14 Mar 2008Cited by 87 (Europe PMC)

PMID18381207 (opens in a new tab)DOI10.1016/j.bbadis.2008.02.011 (opens in a new tab)PepBankPUB-18381207
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, ZO-1 expression did not differ among groups, including ovariectomized mice treated with leuprolide.

    In plain wordsIn mice, ZO-1 expression did not differ among groups, including ovariectomized mice treated with leuprolide.

    Peptide
    Leuprolide
    Outcome
    No significant changeZO-1 expression
    Study

    mousen: not reported in source

    Ovariectomized female mice
    Comparator
    Sham-operated and untreated ovariectomized groups
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression and localization of the cytoplasmic membrane-associated tight junction protein zona occludens 1 (ZO-1) in microvessels was not altered among groups indicating that the increased paracellular permeability was not due to changes in this tight junction protein.
    1 context sentence
    Summary · context
    female mice at 3 months of age were either sham operated (normal serum E2 and gonadotropins), ovariectomized (low serum E2 and high serum gonadotropins) or ovariectomized and treated with the GnRH agonist leuprolide acetate (low serum E2 and gonadotropins).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, ZO-1 localization did not differ among groups, including ovariectomized mice treated with leuprolide.

    In plain wordsIn mice, ZO-1 location did not differ among groups, including ovariectomized mice treated with leuprolide.

    Peptide
    Leuprolide
    Outcome
    No significant changeZO-1 localization
    Study

    mousen: not reported in source

    Ovariectomized female mice
    Comparator
    Sham-operated and untreated ovariectomized groups
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression and localization of the cytoplasmic membrane-associated tight junction protein zona occludens 1 (ZO-1) in microvessels was not altered among groups indicating that the increased paracellular permeability was not due to changes in this tight junction protein.
    1 context sentence
    Summary · context
    female mice at 3 months of age were either sham operated (normal serum E2 and gonadotropins), ovariectomized (low serum E2 and high serum gonadotropins) or ovariectomized and treated with the GnRH agonist leuprolide acetate (low serum E2 and gonadotropins).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In ovariectomized mice, leuprolide suppressed the increase in brain Cx43 expression versus untreated ovariectomized mice.

    In plain wordsIn ovariectomized mice, leuprolide suppressed the increase in brain Cx43 expression versus untreated ovariectomized mice.

    Peptide
    Leuprolide
    Outcome
    DecreaseBrain Cx43 expression
    Study

    mousen: not reported in source

    Ovariectomized female mice
    Comparator
    Untreated ovariectomized mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    An increase in Cx43 expression in the mouse brain following ovariectomy was suppressed in ovariectomized animals treated with leuprolide acetate, indicating that serum gonadotropins rather than sex steroids were modulating Cx43 expression.
    1 context sentence
    Summary · context
    female mice at 3 months of age were either sham operated (normal serum E2 and gonadotropins), ovariectomized (low serum E2 and high serum gonadotropins) or ovariectomized and treated with the GnRH agonist leuprolide acetate (low serum E2 and gonadotropins).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

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