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Study · Animal study (in vivo) · rat · 2008

11 results

Energetic responses are triggered by caudal brainstem melanocortin receptor stimulation and mediated by local sympathetic effector circuits.

Skibicka KP, Grill HJ

Endocrinology27 Mar 2008Cited by 45 (Europe PMC)

PMID18372329 (opens in a new tab)PMCIDPMC2453089 (opens in a new tab)DOI10.1210/en.2007-1754 (opens in a new tab)PepBankPUB-18372329
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In neurologically intact rats, fourth ventricular MTII (0.1 and 1.0 nmol) significantly increased interscapular brown adipose tissue temperature.

    In plain wordsIn rats, melanotan II given into the fourth brain ventricle raised brown fat temperature.

    Peptide
    Melanotan II
    Outcome
    IncreaseInterscapular brown adipose tissue temperature after fourth ventricular MTII
    Study

    ratn: not reported in source

    Neurologically intact rats
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    0.1 and 1.0 nmol · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    Fourth ventricular MTII (0.1, 1.0 nmol) significantly increased T(IBAT), T(C), and HR in intact rats (T(C): +0.33 +/- 0.08, +0.41 +/- 0.09 C; HR: +40.84 +/- 7.29, +69.04 +/- 6.83 beats per minute) and in CDs (T(C): +1.39 +/- 0.67, +1.52 +/- 0.37 C; HR: +83.21 +/- 19.2, +107.38 +/- 17.65 beats per minute).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In neurologically intact rats, fourth ventricular MTII (0.1 and 1.0 nmol) significantly increased core temperature, by 0.33 and 0.41 C.

    In plain wordsIn rats, melanotan II given into the fourth brain ventricle raised core body temperature.

    Peptide
    Melanotan II
    Outcome
    IncreaseCore temperature after fourth ventricular MTII
    Study

    ratn: not reported in source

    Neurologically intact rats
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    0.1 and 1.0 nmol · fourth ventricleAs given in this study (rat).

    Measurements

    Core temperature change
    0.33 C
    0.1 nmol, intact rats
    Core temperature change
    0.41 C
    1.0 nmol, intact rats

    Source sentences

    Summary
    Fourth ventricular MTII (0.1, 1.0 nmol) significantly increased T(IBAT), T(C), and HR in intact rats (T(C): +0.33 +/- 0.08, +0.41 +/- 0.09 C; HR: +40.84 +/- 7.29, +69.04 +/- 6.83 beats per minute) and in CDs (T(C): +1.39 +/- 0.67, +1.52 +/- 0.37 C; HR: +83.21 +/- 19.2, +107.38 +/- 17.65 beats per minute).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In neurologically intact rats, fourth ventricular MTII (0.1 and 1.0 nmol) significantly increased heart rate, by 40.84 and 69.04 beats per minute.

    In plain wordsIn rats, melanotan II given into the fourth brain ventricle raised heart rate.

    Peptide
    Melanotan II
    Outcome
    IncreaseHeart rate after fourth ventricular MTII
    Study

    ratn: not reported in source

    Neurologically intact rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 and 1.0 nmol · fourth ventricleAs given in this study (rat).

    Measurements

    Heart rate change
    40.84 beats per minute
    0.1 nmol, intact rats
    Heart rate change
    69.04 beats per minute
    1.0 nmol, intact rats

    Source sentences

    Summary
    Fourth ventricular MTII (0.1, 1.0 nmol) significantly increased T(IBAT), T(C), and HR in intact rats (T(C): +0.33 +/- 0.08, +0.41 +/- 0.09 C; HR: +40.84 +/- 7.29, +69.04 +/- 6.83 beats per minute) and in CDs (T(C): +1.39 +/- 0.67, +1.52 +/- 0.37 C; HR: +83.21 +/- 19.2, +107.38 +/- 17.65 beats per minute).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In chronic decerebrate rats, fourth ventricular MTII (0.1 and 1.0 nmol) significantly increased interscapular brown adipose tissue temperature.

    In plain wordsIn rats with the forebrain disconnected, melanotan II into the fourth brain ventricle still raised brown fat temperature.

    Peptide
    Melanotan II
    Outcome
    IncreaseInterscapular brown adipose tissue temperature after fourth ventricular MTII in decerebrate rats
    Study

    ratn: not reported in source

    Chronic decerebrate rats
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    0.1 and 1.0 nmol · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    Fourth ventricular MTII (0.1, 1.0 nmol) significantly increased T(IBAT), T(C), and HR in intact rats (T(C): +0.33 +/- 0.08, +0.41 +/- 0.09 C; HR: +40.84 +/- 7.29, +69.04 +/- 6.83 beats per minute) and in CDs (T(C): +1.39 +/- 0.67, +1.52 +/- 0.37 C; HR: +83.21 +/- 19.2, +107.38 +/- 17.65 beats per minute).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In chronic decerebrate rats, fourth ventricular MTII (0.1 and 1.0 nmol) significantly increased core temperature, by 1.39 and 1.52 C.

    In plain wordsIn rats with the forebrain disconnected, melanotan II into the fourth brain ventricle still raised core body temperature.

    Peptide
    Melanotan II
    Outcome
    IncreaseCore temperature after fourth ventricular MTII in decerebrate rats
    Study

    ratn: not reported in source

    Chronic decerebrate rats
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    0.1 and 1.0 nmol · fourth ventricleAs given in this study (rat).

    Measurements

    Core temperature change
    1.39 C
    0.1 nmol, decerebrate rats
    Core temperature change
    1.52 C
    1.0 nmol, decerebrate rats

    Source sentences

    Summary
    Fourth ventricular MTII (0.1, 1.0 nmol) significantly increased T(IBAT), T(C), and HR in intact rats (T(C): +0.33 +/- 0.08, +0.41 +/- 0.09 C; HR: +40.84 +/- 7.29, +69.04 +/- 6.83 beats per minute) and in CDs (T(C): +1.39 +/- 0.67, +1.52 +/- 0.37 C; HR: +83.21 +/- 19.2, +107.38 +/- 17.65 beats per minute).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In chronic decerebrate rats, fourth ventricular MTII (0.1 and 1.0 nmol) significantly increased heart rate, by 83.21 and 107.38 beats per minute.

    In plain wordsIn rats with the forebrain disconnected, melanotan II into the fourth brain ventricle still raised heart rate.

    Peptide
    Melanotan II
    Outcome
    IncreaseHeart rate after fourth ventricular MTII in decerebrate rats
    Study

    ratn: not reported in source

    Chronic decerebrate rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 and 1.0 nmol · fourth ventricleAs given in this study (rat).

    Measurements

    Heart rate change
    83.21 beats per minute
    0.1 nmol, decerebrate rats
    Heart rate change
    107.38 beats per minute
    1.0 nmol, decerebrate rats

    Source sentences

    Summary
    Fourth ventricular MTII (0.1, 1.0 nmol) significantly increased T(IBAT), T(C), and HR in intact rats (T(C): +0.33 +/- 0.08, +0.41 +/- 0.09 C; HR: +40.84 +/- 7.29, +69.04 +/- 6.83 beats per minute) and in CDs (T(C): +1.39 +/- 0.67, +1.52 +/- 0.37 C; HR: +83.21 +/- 19.2, +107.38 +/- 17.65 beats per minute).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    Response to fourth ventricular MTII was greater in chronic decerebrate rats than in neurologically intact rats.

    In plain wordsIn rats, the responses to melanotan II were larger in rats with the forebrain disconnected than in intact rats.

    Peptide
    Melanotan II
    Outcome
    IncreaseResponse magnitude of fourth ventricular MTII, decerebrate versus intact rats
    Study

    ratn: not reported in source

    Intact and chronic decerebrate rats
    Comparator
    Neurologically intact rats
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    0.1 and 1.0 nmol · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    Response magnitude was greater in CD rats than in neurologically intact rats.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In neurologically intact rats, 10 pmol MTII delivered to the medullary raphe significantly increased interscapular brown adipose tissue temperature.

    In plain wordsIn rats, melanotan II given into a hindbrain area called the medullary raphe raised brown fat temperature.

    Peptide
    Melanotan II
    Outcome
    IncreaseInterscapular brown adipose tissue temperature after medullary raphe MTII
    Study

    ratn: not reported in source

    Neurologically intact rats
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    10 pmol · medullary rapheAs given in this study (rat).

    Source sentences

    Summary
    T(IBAT), T(C), and HR were significantly increased after 10 pmol MTII delivery to the medullary raphe of intact rats, and here too, the response magnitude was greater in decerebrate rats.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In neurologically intact rats, 10 pmol MTII delivered to the medullary raphe significantly increased core temperature.

    In plain wordsIn rats, melanotan II given into the medullary raphe raised core body temperature.

    Peptide
    Melanotan II
    Outcome
    IncreaseCore temperature after medullary raphe MTII
    Study

    ratn: not reported in source

    Neurologically intact rats
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    10 pmol · medullary rapheAs given in this study (rat).

    Source sentences

    Summary
    T(IBAT), T(C), and HR were significantly increased after 10 pmol MTII delivery to the medullary raphe of intact rats, and here too, the response magnitude was greater in decerebrate rats.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In neurologically intact rats, 10 pmol MTII delivered to the medullary raphe significantly increased heart rate.

    In plain wordsIn rats, melanotan II given into the medullary raphe raised heart rate.

    Peptide
    Melanotan II
    Outcome
    IncreaseHeart rate after medullary raphe MTII
    Study

    ratn: not reported in source

    Neurologically intact rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10 pmol · medullary rapheAs given in this study (rat).

    Source sentences

    Summary
    T(IBAT), T(C), and HR were significantly increased after 10 pmol MTII delivery to the medullary raphe of intact rats, and here too, the response magnitude was greater in decerebrate rats.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    Response to medullary raphe MTII was greater in decerebrate rats than in intact rats.

    In plain wordsIn rats, the responses to melanotan II in the medullary raphe were larger in rats with the forebrain disconnected than in intact rats.

    Peptide
    Melanotan II
    Outcome
    IncreaseResponse magnitude of medullary raphe MTII, decerebrate versus intact rats
    Study

    ratn: not reported in source

    Intact and chronic decerebrate rats
    Comparator
    Neurologically intact rats
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    10 pmol · medullary rapheAs given in this study (rat).

    Source sentences

    Summary
    and here too, the response magnitude was greater in decerebrate rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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