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Study · In vitro (cells) · mouse · 2008

2 results

[Interaction of the synthetic immunomodulatory dipeptide bestim with murine macrophages and thymocytes].

Kolobov AA, Kolodkin NI, Zolotarev IuA, Tathill C, Navolotskaia EV

Bioorganicheskaia khimiia1 Jan 2008

PMID18365736 (opens in a new tab)DOI10.1134/s1068162008010044 (opens in a new tab)PepBankPUB-18365736
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In murine macrophages, unlabeled thymogen inhibited specific bestim binding with a Ki of 0.9 +/- 0.1 nM.

    In plain wordsIn cells from mice, thymogen inhibited bestim binding to macrophages.

    Peptide
    Thymogen (oglufanide)
    Outcome
    DecreaseBestim binding to macrophages
    Study

    mousen: not reported in source

    peritoneal macrophages
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    Ki
    0.9 nM
    thymogen inhibition of bestim binding to macrophages

    Source sentences

    Summary
    The specific binding of [3H]bestim to macrophages and thymocytes was inhibited by the unlabeled dipeptide thymogen (L-Glu-L-Trp) (Ki 0.9 +/- 0.1 and 1.1 +/- 0.1 nM, respectively).
  2. 02LabIn vitro (cells)Activity measurement

    In murine thymocytes, unlabeled thymogen inhibited specific bestim binding with a Ki of 1.1 +/- 0.1 nM.

    In plain wordsIn cells from mice, thymogen inhibited bestim binding to thymocytes.

    Peptide
    Thymogen (oglufanide)
    Outcome
    DecreaseBestim binding to thymocytes
    Study

    mousen: not reported in source

    thymocytes
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    Ki
    1.1 nM
    thymogen inhibition of bestim binding to thymocytes

    Source sentences

    Summary
    The specific binding of [3H]bestim to macrophages and thymocytes was inhibited by the unlabeled dipeptide thymogen (L-Glu-L-Trp) (Ki 0.9 +/- 0.1 and 1.1 +/- 0.1 nM, respectively).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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