[Dynamics of the behavioral response and cortisole level caused by the combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation in mice under immobilization stress conditions].

Podsevatkin VG, Kiriukhina SV, Podsevatkin DV, Podsevatkina SV, Blinov DS

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2008Cited by 5 (Europe PMC)

PMID18365482PepBankPUB-18365482

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymogen (oglufanide).

01AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In stressed mice, combined mexidole, diazepam, thymogen and hyperbaric oxygenation reduced anxiety.
In plain wordsIn mice under immobilization stress, mexidole, diazepam, thymogen and hyperbaric oxygenation reduced anxiety.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseAnxiety
Study
mousen: not reported in source
immobilization stress
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
a combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation (pathogenetic therapy) leads to optimization of the behavioral reactions, which is manifested by a decrease in the level of anxiety
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-1836548201
02AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In stressed mice, combined mexidole, diazepam, thymogen and hyperbaric oxygenation increased locomotor activity.
In plain wordsIn mice under immobilization stress, mexidole, diazepam, thymogen and hyperbaric oxygenation increased movement.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseLocomotor activity
Study
mousen: not reported in source
immobilization stress
Outcome group
Exercise and physical function · Nervous system and cognition
Source sentences
Summary
a combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation (pathogenetic therapy) leads to optimization of the behavioral reactions, which is manifested by a decrease in the level of anxiety, increase in the locomotor and research activity
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-1836548202
03AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In stressed mice, combined mexidole, diazepam, thymogen and hyperbaric oxygenation increased research activity.
In plain wordsIn mice under immobilization stress, mexidole, diazepam, thymogen and hyperbaric oxygenation increased exploratory activity.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseResearch activity
Study
mousen: not reported in source
immobilization stress
Outcome group
Exercise and physical function · Nervous system and cognition
Source sentences
Summary
a combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation (pathogenetic therapy) leads to optimization of the behavioral reactions, which is manifested by a decrease in the level of anxiety, increase in the locomotor and research activity
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-1836548203
04AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In stressed mice, combined mexidole, diazepam, thymogen and hyperbaric oxygenation normalized cortisole levels.
In plain wordsIn mice under immobilization stress, mexidole, diazepam, thymogen and hyperbaric oxygenation normalized cortisole levels.
Peptide
Thymogen (oglufanide)
Outcome
Direction not reportedCortisole level
Study
mousen: not reported in source
immobilization stress
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
a combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation (pathogenetic therapy) leads to optimization of the behavioral reactions, which is manifested by a decrease in the level of anxiety, increase in the locomotor and research activity, and normalization of the cortisole level.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-1836548204

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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