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Study · Randomized controlled trial · n = 69 · 2008

2 results

Oxytocin enhances the encoding of positive social memories in humans.

Guastella AJ, Mitchell PB, Mathews F

Biological psychiatry17 Mar 2008Cited by 251 (Europe PMC)

PMID18343353 (opens in a new tab)DOI10.1016/j.biopsych.2008.02.008 (opens in a new tab)PepBankPUB-18343353
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men, oxytocin-treated participants made more remember and know judgments for previously seen happy faces than for angry and neutral faces.

    In plain wordsIn healthy men given oxytocin, previously seen happy faces were remembered better than angry and neutral faces.

    Peptide
    Oxytocin
    Outcome
    IncreaseRemember and know judgments for previously seen happy faces
    Study

    n = 69

    Comparator
    Angry and neutral faces
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IUAs given in this study (human).

    Source sentences

    Summary
    Oxytocin-administered participants were more likely to make remember and know judgments for previously seen happy faces compared with angry and neutral human faces.
    1 context sentence
    Summary · context
    In a double-blind, randomized, placebo-controlled, between-subject design, we administered oxytocin (24 IU) or a placebo to 69 healthy human male volunteers and then presented 36 happy, angry, or neutral human faces.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy men, oxytocin did not influence judgments for faces that had not been presented previously.

    In plain wordsIn healthy men, oxytocin did not change judgments about faces they had not seen before.

    Peptide
    Oxytocin
    Outcome
    No significant changeJudgments for faces not previously presented
    Study

    n = 69

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IUAs given in this study (human).

    Source sentences

    Summary
    In contrast, oxytocin did not influence judgments for faces that had not been presented previously.
    1 context sentence
    Summary · context
    In a double-blind, randomized, placebo-controlled, between-subject design, we administered oxytocin (24 IU) or a placebo to 69 healthy human male volunteers and then presented 36 happy, angry, or neutral human faces.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 1NCT03060031

Effects of Intranasal Oxytocin Administration on Social Influence Effects on Pain

University of Colorado, Bouldern = 5121 Jun 2017 to 1 Apr 2019

Pain

Trial pageClinicalTrials.govUpdated 25 Jun 2019

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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