[Delta sleep-inducing peptide and its analogues alleviate the severity of metaphit-induced audiogenic seizures in rats].

Stanojlović O, Hrncić D, Turjacanin D, Zivanović D, Susić V

Medicinski pregled1 Sept 2007

PMID18265587DOI10.2298/mpns0710436sPepBankPUB-18265587

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats with metaphit-induced audiogenic seizures, DSIP significantly increased the power spectra of delta waves.
In plain wordsIn rats with induced seizures, DSIP raised delta wave activity in the brain.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseDelta wave power spectra
Study
ratn: not reported in source
Metaphit-induced audiogenic seizures
Comparator
Metaphit alone
Outcome group
Seizures · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Both DSIP and DSIP analogues significantly increased power spectra of delta waves and decreased the incidence of seizures, as well as mean seizure grade and tonic component of metaphit-induced convulsions.
1 context sentence(design, population, supporting numbers)
Summary · context
Five groups of adult male Wistar rats were intraperitoneally treated with: (1) saline; (2) metaphit: (3) metaphit + DSIP, (4) metaphit + DSIPI-4 and (5) metaphit + DSIP-12.
Report a problemFND-1826558701
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-induced audiogenic seizures, DSIP significantly decreased the incidence of seizures.
In plain wordsIn rats with induced seizures, DSIP lowered how often seizures happened.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseIncidence of metaphit-induced seizures
Study
ratn: not reported in source
Metaphit-induced audiogenic seizures
Comparator
Metaphit alone
Outcome group
Seizures · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Both DSIP and DSIP analogues significantly increased power spectra of delta waves and decreased the incidence of seizures, as well as mean seizure grade and tonic component of metaphit-induced convulsions.
1 context sentence(design, population, supporting numbers)
Summary · context
Five groups of adult male Wistar rats were intraperitoneally treated with: (1) saline; (2) metaphit: (3) metaphit + DSIP, (4) metaphit + DSIPI-4 and (5) metaphit + DSIP-12.
Report a problemFND-1826558702
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-induced audiogenic seizures, DSIP significantly decreased the mean seizure grade.
In plain wordsIn rats with induced seizures, DSIP lowered how severe seizures were.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseMean seizure grade
Study
ratn: not reported in source
Metaphit-induced audiogenic seizures
Comparator
Metaphit alone
Outcome group
Seizures · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Both DSIP and DSIP analogues significantly increased power spectra of delta waves and decreased the incidence of seizures, as well as mean seizure grade and tonic component of metaphit-induced convulsions.
1 context sentence(design, population, supporting numbers)
Summary · context
Five groups of adult male Wistar rats were intraperitoneally treated with: (1) saline; (2) metaphit: (3) metaphit + DSIP, (4) metaphit + DSIPI-4 and (5) metaphit + DSIP-12.
Report a problemFND-1826558703
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-induced audiogenic seizures, DSIP significantly decreased the tonic component of convulsions.
In plain wordsIn rats with induced seizures, DSIP reduced the tonic (stiffening) part of convulsions.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseTonic component of convulsions
Study
ratn: not reported in source
Metaphit-induced audiogenic seizures
Comparator
Metaphit alone
Outcome group
Seizures · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Both DSIP and DSIP analogues significantly increased power spectra of delta waves and decreased the incidence of seizures, as well as mean seizure grade and tonic component of metaphit-induced convulsions.
1 context sentence(design, population, supporting numbers)
Summary · context
Five groups of adult male Wistar rats were intraperitoneally treated with: (1) saline; (2) metaphit: (3) metaphit + DSIP, (4) metaphit + DSIPI-4 and (5) metaphit + DSIP-12.
Report a problemFND-1826558704

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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