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Study · Measured the body's own peptide · 2008

2 results

The role of the arginine vasopressin Avp1b receptor in the acute neuroendocrine action of antidepressants.

Stewart LQ, Roper JA, Young WS 3rd, O'Carroll AM, Lolait SJ

Psychoneuroendocrinology4 Feb 2008Cited by 32 (Europe PMC)

PMID18243568 (opens in a new tab)DOI10.1016/j.psyneuen.2007.12.009 (opens in a new tab)PepBankPUB-18243568
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male Avpr1b knockout and wild-type mice, fluoxetine did not change the body's own oxytocin mRNA expression in the hypothalamic paraventricular nucleus.

    In plain wordsIn male mice, fluoxetine did not change the body's own oxytocin gene activity in the hypothalamus.

    Peptide
    Oxytocin
    Outcome
    No significant changePVN oxytocin mRNA in fluoxetine-treated male mice
    Study

    mousen: not reported in source

    Avpr1b knockout and wild-type mice treated with fluoxetine
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Avp, oxytocin (Oxt) and Crh mRNA expression in the PVN did not change in fluoxetine-treated male Avpr1b KO or wild-type mice.
    1 context sentence
    Summary · context
    We measured plasma ACTH and corticosterone (CORT) levels and neuropeptide mRNA expression in the hypothalamic paraventricular nucleus (PVN) of Avpr1b knockout (KO) mice and wild-type controls.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In female mice of both genotypes, fluoxetine treatment increased the body's own oxytocin mRNA levels in the hypothalamic paraventricular nucleus.

    In plain wordsIn female mice, fluoxetine raised the body's own oxytocin gene activity in the hypothalamus.

    Peptide
    Oxytocin
    Outcome
    IncreasePVN oxytocin mRNA in fluoxetine-treated female mice
    Study

    mousen: not reported in source

    Avpr1b knockout and wild-type mice treated with fluoxetine
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    PVN Oxt mRNA levels increased in fluoxetine-treated female mice of both genotypes.
    1 context sentence
    Summary · context
    We measured plasma ACTH and corticosterone (CORT) levels and neuropeptide mRNA expression in the hypothalamic paraventricular nucleus (PVN) of Avpr1b knockout (KO) mice and wild-type controls.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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