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Study · Animal study (in vivo) · mouse · 2007

2 results

Effect of compound GB-115 on morphine-induced analgesia.

Kolik LG, Zhukov VN, Seredenin SB

Bulletin of experimental biology and medicine1 Jun 2007Cited by 2 (Europe PMC)

PMID18239806 (opens in a new tab)DOI10.1007/s10517-007-0219-3 (opens in a new tab)PepBankPUB-18239806
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In outbred mice, GB‑115 potentiated morphine-induced analgesia in the hot-plate test through a naloxone-dependent effect.

    In plain wordsIn mice, GB‑115 increased morphine-induced pain relief in the hot-plate test.

    Peptide
    GB-115
    Outcome
    IncreaseHot-plate analgesia
    Study

    mousen: not reported in source

    outbred mice
    Comparator
    Morphine without GB-115
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Experiments on outbred mice showed that compound GB-115, a retropeptide analogue of the tetrapeptide cholecystokinin, produced a naloxone-dependent potentiating effect on morphine-induced analgesia in the hot-plate test, but did not modulate animal behavior in the tail-flick test in outbred mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In outbred mice, GB‑115 did not modulate behavior in the morphine tail-flick test.

    In plain wordsIn mice, GB‑115 did not change behavior in the morphine tail-flick test.

    Peptide
    GB-115
    Outcome
    No significant changeTail-flick behavior
    Study

    mousen: not reported in source

    outbred mice
    Comparator
    Morphine without GB-115
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Experiments on outbred mice showed that compound GB-115, a retropeptide analogue of the tetrapeptide cholecystokinin, produced a naloxone-dependent potentiating effect on morphine-induced analgesia in the hot-plate test, but did not modulate animal behavior in the tail-flick test in outbred mice.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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