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Study · In vitro (cells) · 2007

3 results

Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity.

Storozhevykh TP, Tukhbatova GR, Senilova YE, Pinelis VG, Andreeva LA, Myasoyedov NF

Bulletin of experimental biology and medicine1 May 2007Cited by 21 (Europe PMC)

PMID18239779 (opens in a new tab)DOI10.1007/s10517-007-0192-x (opens in a new tab)PepBankPUB-18239779
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured cerebellar granule cells under glutamate neurotoxicity, Semax at 100 microM delayed the development of calcium dysregulation.

    In plain wordsIn cells in a dish, Semax delayed the loss of calcium control caused by glutamate toxicity.

    Peptide
    Semax
    Outcome
    DecreaseCalcium dysregulation under glutamate toxicity
    Study

    n: not reported in source

    Cultured cerebellar granule cells under glutamate neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 microMAs given in this study.

    Source sentences

    Summary
    Semax (100 microM) and its Pro-Gly-Pro fragment (20 and 100 microM) delayed the development of calcium dysregulation and reduction of the mitochondrial potential in cultured cerebellar granule cells under conditions of glutamate neurotoxicity.
  2. 02LabIn vitro (cells)Mechanism

    In cultured cerebellar granule cells under glutamate neurotoxicity, Semax at 100 microM delayed the reduction of mitochondrial potential.

    In plain wordsIn cells in a dish, Semax delayed the drop in mitochondrial potential caused by glutamate toxicity.

    Peptide
    Semax
    Outcome
    IncreaseMitochondrial potential under glutamate toxicity
    Study

    n: not reported in source

    Cultured cerebellar granule cells under glutamate neurotoxicity
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    100 microMAs given in this study.

    Source sentences

    Summary
    Semax (100 microM) and its Pro-Gly-Pro fragment (20 and 100 microM) delayed the development of calcium dysregulation and reduction of the mitochondrial potential in cultured cerebellar granule cells under conditions of glutamate neurotoxicity.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cultured cerebellar granule cells under glutamate neurotoxicity, incubation with Semax and Pro-Gly-Pro improved neuronal survival by on average 30%.

    In plain wordsIn cells in a dish, Semax (with Pro-Gly-Pro) improved neuron survival by about 30% under glutamate toxicity.

    Peptide
    Semax
    Outcome
    IncreaseNeuronal survival under glutamate toxicity
    Study

    n: not reported in source

    Cultured cerebellar granule cells under glutamate neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 microMAs given in this study.

    Measurements

    Neuronal survival improvement
    30%
    on average, with these peptides

    Source sentences

    Summary
    Incubation with these peptides improved neuronal survival by on average 30%.
    1 context sentence
    Summary · context
    Semax (100 microM) and its Pro-Gly-Pro fragment (20 and 100 microM) delayed the development of calcium dysregulation and reduction of the mitochondrial potential in cultured cerebellar granule cells under conditions of glutamate neurotoxicity.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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