In mice lacking the oxytocin gene, phencyclidine caused large prepulse inhibition deficits that did not occur in wild-type mice.
In plain wordsIn mice bred without oxytocin, a psychosis-inducing drug caused large sensory-gating deficits that normal mice did not show.
- Peptide
- Oxytocin
- Outcome
- DecreasePCP-induced prepulse inhibition deficit in oxytocin-knockout mice
- Study
mousen: not reported in source
Oxt-/- knockout mice- Comparator
- Oxt+/+ mice
- Outcome group
- Locomotor and behavioral activity · Nervous system and cognition
Source sentences
However, in Oxt-/- mice, but not Oxt+/+ mice, PCP treatment resulted in large PPI deficits.
1 context sentence(design, population, supporting numbers)
To test this hypothesis, we investigated whether disruption of the oxytocin gene (Oxt-/-) made mice more susceptible to the psychosis-related effects of amphetamine (Amp), apomorphine (Apo) and phencyclidine (PCP).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.