In vitro effect of thymosin-alpha1 and interferon-alpha on Th1 and Th2 cytokine synthesis in patients with eAg-negative chronic hepatitis B.

Loggi E, Gramenzi A, Margotti M, Cursaro C, Galli S, Vitale G, Grandini E, Scuteri A, Vukotic R, Andreone P, Bernardi M

Journal of viral hepatitis22 Jan 2008Cited by 12 (Europe PMC)

PMID18221304DOI10.1111/j.1365-2893.2007.00960.xPepBankPUB-18221304

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In PBMCs from patients with eAg-negative chronic hepatitis B, Talpha1 alone reversed the IFNalpha-induced rise in IL-10 synthesis.
In plain wordsIn lab tests on immune cells from hepatitis B blood samples, thymosin alpha‑1 alone reversed the interferon-driven rise in IL-10.
Peptide
Thymosin alpha-1
Outcome
DecreaseIFN-induced IL-10 synthesis
Study
humann = 12
PBMCs from patients with eAg-negative chronic hepatitis B
Comparator
Baseline (no incubation with Talpha1)
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Interestingly, both Talpha1 alone and the IFNalpha/Talpha1 combination reversed this effect.
2 context sentences(design, population, supporting numbers)
Summary · context
In these latter, IFNalpha increased the synthesis of IL-10 compared with baseline.
Summary · context
This study investigated the effect of Talpha1 and interferon-alpha (IFNalpha) on cytokine production by peripheral blood mononuclear cells (PBMCs) of 12 patients with eAg-negative chronic hepatitis B (HBV).
Report a problemFND-1822130401
02LabEx vivo tissueActivity measurement
In PBMCs from patients with eAg-negative chronic hepatitis B, Talpha1 alone significantly increased synthesis of the antiviral protein 2',5'-OAS compared with baseline.
In plain wordsIn lab tests on immune cells from hepatitis B blood samples, thymosin alpha‑1 alone raised an antiviral protein compared with baseline.
Peptide
Thymosin alpha-1
Outcome
Increase2',5'-OAS synthesis
Study
humann = 12
PBMCs from patients with eAg-negative chronic hepatitis B
Comparator
Baseline (no incubation with Talpha1)
Outcome group
Antiviral activity · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Finally, compared with baseline, the synthesis of 2',5'-OAS was significantly higher in the presence of Talpha1 and IFNalpha alone, and in the presence of IFNalpha/Talpha1 association, while no differences were found between controls and HBV patients.
1 context sentence(design, population, supporting numbers)
Summary · context
This study investigated the effect of Talpha1 and interferon-alpha (IFNalpha) on cytokine production by peripheral blood mononuclear cells (PBMCs) of 12 patients with eAg-negative chronic hepatitis B (HBV).
Report a problemFND-1822130404

Studies that did not test the peptide alone3

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

03LabNot a test of Thymosin alpha-1 aloneEx vivo tissueActivity measurement
In PBMCs from patients with eAg-negative chronic hepatitis B, the IFNalpha/Talpha1 combination reversed the IFNalpha-induced rise in IL-10 synthesis.
In plain wordsIn lab tests on immune cells from hepatitis B blood samples, interferon plus thymosin alpha‑1 reversed the interferon-driven rise in IL-10.
Peptide
Thymosin alpha-1
Outcome
DecreaseIFN-induced IL-10 synthesis
Study
humann = 12
PBMCs from patients with eAg-negative chronic hepatitis B
Comparator
Baseline (no incubation with Talpha1)
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Interestingly, both Talpha1 alone and the IFNalpha/Talpha1 combination reversed this effect.
2 context sentences(design, population, supporting numbers)
Summary · context
In these latter, IFNalpha increased the synthesis of IL-10 compared with baseline.
Summary · context
This study investigated the effect of Talpha1 and interferon-alpha (IFNalpha) on cytokine production by peripheral blood mononuclear cells (PBMCs) of 12 patients with eAg-negative chronic hepatitis B (HBV).
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.
Report a problemFND-1822130402
04LabNot a test of Thymosin alpha-1 aloneEx vivo tissueActivity measurement
In PBMCs from patients with eAg-negative chronic hepatitis B, the IFNalpha/Talpha1 combination significantly increased IL-2 production compared with baseline.
In plain wordsIn lab tests on immune cells from hepatitis B blood samples, interferon plus thymosin alpha‑1 raised IL-2 production compared with baseline.
Peptide
Thymosin alpha-1
Outcome
IncreaseIL-2 production
Study
humann = 12
PBMCs from patients with eAg-negative chronic hepatitis B
Comparator
Baseline (no incubation with Talpha1)
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
In HBV setting, IFNalpha/Talpha1 combination was able to increase IL-2 production significantly, when compared with baseline condition.
1 context sentence(design, population, supporting numbers)
Summary · context
This study investigated the effect of Talpha1 and interferon-alpha (IFNalpha) on cytokine production by peripheral blood mononuclear cells (PBMCs) of 12 patients with eAg-negative chronic hepatitis B (HBV).
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.
Report a problemFND-1822130403
05LabNot a test of Thymosin alpha-1 aloneEx vivo tissueActivity measurement
In PBMCs from patients with eAg-negative chronic hepatitis B, the IFNalpha/Talpha1 combination significantly increased 2',5'-OAS synthesis compared with baseline.
In plain wordsIn lab tests on immune cells from hepatitis B blood samples, interferon plus thymosin alpha‑1 raised an antiviral protein compared with baseline.
Peptide
Thymosin alpha-1
Outcome
Increase2',5'-OAS synthesis
Study
humann = 12
PBMCs from patients with eAg-negative chronic hepatitis B
Comparator
Baseline (no incubation with Talpha1)
Outcome group
Antiviral activity · Immune and inflammation
Source sentences
Summary
Finally, compared with baseline, the synthesis of 2',5'-OAS was significantly higher in the presence of Talpha1 and IFNalpha alone, and in the presence of IFNalpha/Talpha1 association, while no differences were found between controls and HBV patients.
1 context sentence(design, population, supporting numbers)
Summary · context
This study investigated the effect of Talpha1 and interferon-alpha (IFNalpha) on cytokine production by peripheral blood mononuclear cells (PBMCs) of 12 patients with eAg-negative chronic hepatitis B (HBV).
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.
Report a problemFND-1822130405

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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