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Study · In vitro (cells) · 2007

3 results

NAP, a neuroprotective drug candidate in clinical trials, stimulates microtubule assembly in the living cell.

Gozes I, Divinski I

Current Alzheimer research1 Dec 2007Cited by 56 (Europe PMC)

PMID18220512 (opens in a new tab)DOI10.2174/156720507783018208 (opens in a new tab)PepBankPUB-18220512
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cells after nocodazole-induced depolymerization, NAP enhanced rapid microtubule assembly.

    In plain wordsIn cells after nocodazole exposure, NAP increased rapid microtubule assembly.

    Peptide
    Davunetide
    Outcome
    IncreaseMicrotubule assembly after nocodazole
    Study

    n: not reported in source

    Living cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, following microtubule depolymerization in the presence of nocodazole, NAP treatment enhanced rapid microtubule assembly and stimulated neurite outgrowth.
  2. 02LabIn vitro (cells)Mechanism

    In cells after nocodazole-induced depolymerization, NAP stimulated neurite outgrowth.

    In plain wordsIn cells after nocodazole exposure, NAP stimulated nerve extension growth.

    Peptide
    Davunetide
    Outcome
    IncreaseNeurite outgrowth after nocodazole
    Study

    n: not reported in source

    Living cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, following microtubule depolymerization in the presence of nocodazole, NAP treatment enhanced rapid microtubule assembly and stimulated neurite outgrowth.
  3. 03LabIn vitro (cells)Mechanism

    In cell experiments, NAP did not affect dividing cells.

    In plain wordsIn cells, NAP did not affect dividing cells.

    Peptide
    Davunetide
    Outcome
    No significant changeEffect on dividing cells
    Study

    n: not reported in source

    Living cells
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NAP shows selectivity in interacting with brain tubulin and does not affect dividing cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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