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Study · Measured the body's own peptide · 2008

1 result

Increased workload fully activates the blunted IRS-1/PI3-kinase/Akt signaling pathway in atrophied uremic muscle.

Chen Y, Sood S, Biada J, Roth R, Rabkin R

Kidney international23 Jan 2008Cited by 25 (Europe PMC)

PMID18216779 (opens in a new tab)DOI10.1038/sj.ki.5002801 (opens in a new tab)PepBankPUB-18216779
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In uremic and control rats, surgically induced work overload increased muscle mechano-growth factor (MGF) expression.

    In plain wordsIn rats, work overload raised the body's own MGF expression in the overloaded muscle.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMuscle MGF expression after work overload
    Study

    ratn: not reported in source

    Uremic and control rats with unilateral plantaris work overload
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    We found that work overload increases muscle insulin-like growth factor-1 and mechano-growth factor expression.
    1 context sentence
    Summary · context
    To study the mechanism by which this occurs, we compared uremic and control rats where work overload was surgically induced unilaterally in the plantaris muscle.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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