Use of Selank to correct measures of integrative brain activity and biogenic amine levels in adult rats resulting from antenatal hypoxia.

Semenova TP, Kozlovskaya MM, Zuikov AV, Kozlovskii II, Zakharova NM, Andreeva LA

Neuroscience and behavioral physiology1 Feb 2008Cited by 2 (Europe PMC)

PMID18197389DOI10.1007/s11055-008-0030-2PepBankPUB-18197389

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In adult rats exposed to antenatal hypoxia, Selank improved sensory attention levels by factors of 2-3.
In plain wordsIn rats exposed to low oxygen before birth, Selank improved attention to sensory stimuli.
Peptide
Selank
Outcome
IncreaseSensory attention level
Study
ratn: not reported in source
antenatal hypoxia on gestation days 14-16
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
300 microg/kg · intraperitonealAs given in this study (rat).
Measurements
Sensory attention improvement
2 to 3 fold
Selank 300 microg/kg
Source sentences
Summary
Administration of Selank (300 microg/kg, i.p.) improved sensory attention levels by factors of 2-3 (p < 0.01)
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of Selank, the active component of which is the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro, which includes the tetrapeptide tuftsin and three natural levorotatory amino acids, on behavior and brain serotonin and noradrenaline levels were studied in adult rats subjected to antenatal hypoxia…
Report a problemFND-1819738901
02AnimalAnimal study (in vivo)Efficacy outcome
In adult rats exposed to antenatal hypoxia, Selank facilitated the learning process by a factor of 1.5.
In plain wordsIn rats exposed to low oxygen before birth, Selank improved learning.
Peptide
Selank
Outcome
IncreaseLearning
Study
ratn: not reported in source
antenatal hypoxia on gestation days 14-16
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
300 microg/kg · intraperitonealAs given in this study (rat).
Measurements
Learning improvement
1.5 fold
Selank 300 microg/kg
Source sentences
Summary
facilitated the learning process by a factor of 1.5 (p < 0.01)
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of Selank, the active component of which is the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro, which includes the tetrapeptide tuftsin and three natural levorotatory amino acids, on behavior and brain serotonin and noradrenaline levels were studied in adult rats subjected to antenatal hypoxia…
Report a problemFND-1819738902
03AnimalAnimal study (in vivo)Efficacy outcome
In adult rats exposed to antenatal hypoxia, Selank normalized the level of investigative activity in the open field.
In plain wordsIn rats exposed to low oxygen before birth, Selank brought exploring behaviour in an open field back to a normal level.
Peptide
Selank
Outcome
Direction not reportedInvestigative activity in open field
Study
ratn: not reported in source
antenatal hypoxia on gestation days 14-16
Outcome group
Anxiety and mood · Nervous system and cognition
Studied dose
300 microg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
normalized the level of investigative activity in the open field and hole board
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of Selank, the active component of which is the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro, which includes the tetrapeptide tuftsin and three natural levorotatory amino acids, on behavior and brain serotonin and noradrenaline levels were studied in adult rats subjected to antenatal hypoxia…
Report a problemFND-1819738903
04AnimalAnimal study (in vivo)Efficacy outcome
In adult rats exposed to antenatal hypoxia, Selank normalized the level of investigative activity in the hole board test.
In plain wordsIn rats exposed to low oxygen before birth, Selank brought exploring behaviour in a hole board test back to a normal level.
Peptide
Selank
Outcome
Direction not reportedInvestigative activity in hole board
Study
ratn: not reported in source
antenatal hypoxia on gestation days 14-16
Outcome group
Anxiety and mood · Nervous system and cognition
Studied dose
300 microg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
normalized the level of investigative activity in the open field and hole board
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of Selank, the active component of which is the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro, which includes the tetrapeptide tuftsin and three natural levorotatory amino acids, on behavior and brain serotonin and noradrenaline levels were studied in adult rats subjected to antenatal hypoxia…
Report a problemFND-1819738904
05AnimalAnimal study (in vivo)Mechanism
In adult rats exposed to antenatal hypoxia, Selank restored the balance of activity between the serotoninergic and noradrenergic systems of the brain.
In plain wordsIn rats exposed to low oxygen before birth, Selank restored the balance between two brain signalling systems.
Peptide
Selank
Outcome
Direction not reportedBalance of serotoninergic and noradrenergic activity
Study
ratn: not reported in source
antenatal hypoxia on gestation days 14-16
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
300 microg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
restored the balance of activity between the serotoninergic and noradrenergic systems of the brain.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of Selank, the active component of which is the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro, which includes the tetrapeptide tuftsin and three natural levorotatory amino acids, on behavior and brain serotonin and noradrenaline levels were studied in adult rats subjected to antenatal hypoxia…
Report a problemFND-1819738905

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

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