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Study · Animal study (in vivo) · rat · 2008

7 results

Effects of melanotan II, a melanocortin agonist, on grooming and exploration in rats after repeated restraint/immobilization.

Klenerová V, Krejcí I, Sída P, Hlinák Z, Hynie S

Neuroscience letters11 Jan 2008Cited by 13 (Europe PMC)

PMID18191328 (opens in a new tab)DOI10.1016/j.neulet.2007.12.020 (opens in a new tab)PepBankPUB-18191328
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In naive rats in an unfamiliar open field, a single 2 mg/kg intraperitoneal dose of melanotan II increased grooming without changing locomotion or rearing.

    In plain wordsIn rats, a single dose of melanotan II increased grooming without changing movement or rearing.

    Peptide
    Melanotan II
    Outcome
    IncreaseGrooming in naive rats
    Study

    ratn: not reported in source

    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    2 mg/kg · intraperitoneal · single doseAs given in this study (rat).

    Source sentences

    Summary
    2mg/kg melanotan II (MTII, administered i.p.), a cyclic peptide analog of alpha-melanocyte stimulating hormone, at a single dose increased grooming in naive rats placed in an unfamiliar open-field device without changing locomotion or rearing.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In naive rats, a single 2 mg/kg intraperitoneal dose of melanotan II did not change locomotion or rearing.

    In plain wordsIn rats, a single dose of melanotan II did not change movement or rearing.

    Peptide
    Melanotan II
    Outcome
    No significant changeLocomotion and rearing in naive rats
    Study

    ratn: not reported in source

    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    2 mg/kg · intraperitoneal · single doseAs given in this study (rat).

    Source sentences

    Summary
    without changing locomotion or rearing.
    1 context sentence
    Summary · context
    2mg/kg melanotan II (MTII, administered i.p.), a cyclic peptide analog of alpha-melanocyte stimulating hormone, at a single dose increased grooming in naive rats placed in an unfamiliar open-field device
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to restraint/immobilization stress, melanotan II given after stress enhanced grooming compared with pre-stress and post-stress values.

    In plain wordsIn stressed rats, melanotan II increased grooming compared with the levels before and after stress.

    Peptide
    Melanotan II
    Outcome
    IncreaseGrooming after restraint stress
    Study

    ratn: not reported in source

    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTII, administered to the rats after IS, enhanced the grooming response compared both to the pre- and post-stress values.
    1 context sentence
    Summary · context
    Male rats exposed to restraint/immobilization stress (IS) for 1h on three consecutive days displayed increased grooming after the second stressor exposure, compared to pre-stress levels.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In stressed rats, melanotan II did not influence the reduction in distance moved that the stressor caused.

    In plain wordsIn stressed rats, melanotan II did not change the drop in movement caused by stress.

    Peptide
    Melanotan II
    Outcome
    No significant changeDistance moved after restraint stress
    Study

    ratn: not reported in source

    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    As to the locomotion of rats in the entire experimental space, IS reduced the distance moved only after the first two stressor exposures; MTII did not influence these alterations.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In stressed rats, the only change in rearing was an increase in the melanotan II group after the third restraint exposure.

    In plain wordsIn stressed rats, melanotan II was linked to more rearing after the third stress exposure.

    Peptide
    Melanotan II
    Outcome
    IncreaseRearing after restraint stress
    Study

    ratn: not reported in source

    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The only observed change in rearing was an increase in the MTII group after the third restraint exposure.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In stressed rats, locomotion in the central part of the arena was not reduced by melanotan II, and rose in both the stressed and melanotan II groups after the third intervention.

    In plain wordsIn stressed rats, melanotan II did not reduce movement in the centre of the arena.

    Peptide
    Melanotan II
    Outcome
    No significant changeLocomotion in the central arena after restraint stress
    Study

    ratn: not reported in source

    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Locomotion in the central part of arena was not reduced by the stressor or by MTII, on the contrary, there was an increase in both groups after the third intervention.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats given melanotan II after restraint/immobilization stress, the increase in grooming was greatest after the first dose and declined over the following two applications.

    In plain wordsIn rats, the grooming increase caused by melanotan II after stress was largest after the first dose and then got smaller.

    Peptide
    Melanotan II
    Outcome
    DecreaseChange in melanotan II enhanced grooming over repeated stress sessions
    Study

    ratn: not reported in source

    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The increase was greatest after the first dose and declined over the following two applications.
    1 context sentence
    Summary · context
    MTII, administered to the rats after IS, enhanced the grooming response compared both to the pre- and post-stress values.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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