Changes at the focus of experimental ischemic stroke treated with neuroprotective agents.

Onishchenko LS, Gaikova ON, Yanishevskii SN

Neuroscience and behavioral physiology1 Jan 2008Cited by 18 (Europe PMC)

PMID18097760DOI10.1007/s11055-008-0007-1PepBankPUB-18097760

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats with experimental ischemic stroke, Cerebrolysin increased neuronal tolerance to ischemic damage.
In plain wordsIn rats with experimental ischemic stroke, Cerebrolysin increased neuronal tolerance to ischemic damage.
Peptide
Cerebrolysin
Outcome
IncreaseNeuronal tolerance to ischemic damage
Study
ratn: not reported in source
Experimental ischemic stroke
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Use of alpha-GPC and cerebrolysin increased the tolerance of neurons to ischemic damage and slowed the execution of the cell death program.
1 context sentence(design, population, supporting numbers)
Summary · context
Experiments were performed on 18 rats. Transient cerebral circulatory lesions (acute ischemia) were produced in the right hemisphere by clipping the stem of the innominate artery for 40 min.
Report a problemFND-1809776001
02AnimalAnimal study (in vivo)Mechanism
In rats with experimental ischemic stroke, Cerebrolysin slowed execution of the cell death program.
In plain wordsIn rats with experimental ischemic stroke, Cerebrolysin slowed the cell death program.
Peptide
Cerebrolysin
Outcome
DecreaseExecution of cell death program
Study
ratn: not reported in source
Experimental ischemic stroke
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Use of alpha-GPC and cerebrolysin increased the tolerance of neurons to ischemic damage and slowed the execution of the cell death program.
1 context sentence(design, population, supporting numbers)
Summary · context
Experiments were performed on 18 rats. Transient cerebral circulatory lesions (acute ischemia) were produced in the right hemisphere by clipping the stem of the innominate artery for 40 min.
Report a problemFND-1809776002
03AnimalAnimal study (in vivo)Mechanism
In rats with experimental ischemic stroke, Cerebrolysin-associated intracellular changes included nuclear membrane folding, interpreted as adaptive and reparative.
In plain wordsIn rats with experimental ischemic stroke, Cerebrolysin-associated cell changes included nuclear membrane folding.
Peptide
Cerebrolysin
Outcome
Not applicableNuclear membrane folding
Study
ratn: not reported in source
Experimental ischemic stroke
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Intracellular changes were seen and were interpreted as adaptive and reparative: these included folding of the nuclear membrane, abundance of polyribosomes, and endoplasmic reticulum and Golgi complex hypertrophy.
2 context sentences(design, population, supporting numbers)
Summary · context
Use of alpha-GPC and cerebrolysin increased the tolerance of neurons to ischemic damage and slowed the execution of the cell death program.
Summary · context
Experiments were performed on 18 rats. Transient cerebral circulatory lesions (acute ischemia) were produced in the right hemisphere by clipping the stem of the innominate artery for 40 min.
Report a problemFND-1809776003
04AnimalAnimal study (in vivo)Mechanism
In rats with experimental ischemic stroke, Cerebrolysin-associated intracellular changes included abundant polyribosomes, interpreted as adaptive and reparative.
In plain wordsIn rats with experimental ischemic stroke, Cerebrolysin-associated cell changes included abundant polyribosomes.
Peptide
Cerebrolysin
Outcome
Not applicablePolyribosome abundance
Study
ratn: not reported in source
Experimental ischemic stroke
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Intracellular changes were seen and were interpreted as adaptive and reparative: these included folding of the nuclear membrane, abundance of polyribosomes, and endoplasmic reticulum and Golgi complex hypertrophy.
2 context sentences(design, population, supporting numbers)
Summary · context
Use of alpha-GPC and cerebrolysin increased the tolerance of neurons to ischemic damage and slowed the execution of the cell death program.
Summary · context
Experiments were performed on 18 rats. Transient cerebral circulatory lesions (acute ischemia) were produced in the right hemisphere by clipping the stem of the innominate artery for 40 min.
Report a problemFND-1809776004
05AnimalAnimal study (in vivo)Mechanism
In rats with experimental ischemic stroke, Cerebrolysin-associated intracellular changes included endoplasmic reticulum hypertrophy.
In plain wordsIn rats with experimental ischemic stroke, Cerebrolysin-associated cell changes included enlarged endoplasmic reticulum.
Peptide
Cerebrolysin
Outcome
IncreaseEndoplasmic reticulum hypertrophy
Study
ratn: not reported in source
Experimental ischemic stroke
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Intracellular changes were seen and were interpreted as adaptive and reparative: these included folding of the nuclear membrane, abundance of polyribosomes, and endoplasmic reticulum and Golgi complex hypertrophy.
2 context sentences(design, population, supporting numbers)
Summary · context
Use of alpha-GPC and cerebrolysin increased the tolerance of neurons to ischemic damage and slowed the execution of the cell death program.
Summary · context
Experiments were performed on 18 rats. Transient cerebral circulatory lesions (acute ischemia) were produced in the right hemisphere by clipping the stem of the innominate artery for 40 min.
Report a problemFND-1809776005
06AnimalAnimal study (in vivo)Mechanism
In rats with experimental ischemic stroke, Cerebrolysin-associated intracellular changes included Golgi complex hypertrophy.
In plain wordsIn rats with experimental ischemic stroke, Cerebrolysin-associated cell changes included enlarged Golgi complexes.
Peptide
Cerebrolysin
Outcome
IncreaseGolgi complex hypertrophy
Study
ratn: not reported in source
Experimental ischemic stroke
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Intracellular changes were seen and were interpreted as adaptive and reparative: these included folding of the nuclear membrane, abundance of polyribosomes, and endoplasmic reticulum and Golgi complex hypertrophy.
2 context sentences(design, population, supporting numbers)
Summary · context
Use of alpha-GPC and cerebrolysin increased the tolerance of neurons to ischemic damage and slowed the execution of the cell death program.
Summary · context
Experiments were performed on 18 rats. Transient cerebral circulatory lesions (acute ischemia) were produced in the right hemisphere by clipping the stem of the innominate artery for 40 min.
Report a problemFND-1809776006
07AnimalAnimal study (in vivo)Mechanism
In rats with experimental ischemic stroke, Cerebrolysin preserved nuclear membrane structures.
In plain wordsIn rats with experimental ischemic stroke, Cerebrolysin preserved nuclear membrane structures.
Peptide
Cerebrolysin
Outcome
Not applicableNuclear membrane structure preservation
Study
ratn: not reported in source
Experimental ischemic stroke
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
These agents preserved the structures of the nuclear membranes and major cellular organelles.
2 context sentences(design, population, supporting numbers)
Summary · context
Use of alpha-GPC and cerebrolysin increased the tolerance of neurons to ischemic damage and slowed the execution of the cell death program.
Summary · context
Experiments were performed on 18 rats. Transient cerebral circulatory lesions (acute ischemia) were produced in the right hemisphere by clipping the stem of the innominate artery for 40 min.
Report a problemFND-1809776007
08AnimalAnimal study (in vivo)Mechanism
In rats with experimental ischemic stroke, Cerebrolysin preserved major cellular organelle structures.
In plain wordsIn rats with experimental ischemic stroke, Cerebrolysin preserved major cellular organelle structures.
Peptide
Cerebrolysin
Outcome
Not applicableMajor cellular organelle structure preservation
Study
ratn: not reported in source
Experimental ischemic stroke
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
These agents preserved the structures of the nuclear membranes and major cellular organelles.
2 context sentences(design, population, supporting numbers)
Summary · context
Use of alpha-GPC and cerebrolysin increased the tolerance of neurons to ischemic damage and slowed the execution of the cell death program.
Summary · context
Experiments were performed on 18 rats. Transient cerebral circulatory lesions (acute ischemia) were produced in the right hemisphere by clipping the stem of the innominate artery for 40 min.
Report a problemFND-1809776008

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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