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Study · Not a test of the peptide alone · 2008

4 results

Near infrared spectroscopy compared to liquid chromatography coupled to mass spectrometry and capillary electrophoresis as a detection tool for peptide reaction monitoring.

Petter CH, Heigl N, Bachmann S, Huck-Pezzei VA, Najam-Ul-Haq M, Bakry R, Bernkop-Schnürch A, Bonn GK, Huck CW

Amino acids20 Dec 2007Cited by 5 (Europe PMC)

PMID18095054 (opens in a new tab)DOI10.1007/s00726-007-0014-5 (opens in a new tab)PepBankPUB-18095054
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    In a glutathione and oxytocin reaction at pH 3, LC-UV and LC-ESI-MS measured 82% and 78% degradation of oxytocin.

    In plain wordsIn lab tests at pH 3, two chemical methods found that most oxytocin degraded.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin degradation at pH 3 by LC-UV and LC-ESI-MS
    Study

    n: not reported in source

    Glutathione and oxytocin reaction mixture
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Measurements

    Oxytocin degradation by LC-UV
    82%
    pH 3
    Oxytocin degradation by LC-ESI-MS
    78%
    pH 3

    Source sentences

    Summary
    Liquid chromatography coupled to UV (LC-UV) and mass spectrometry via an electrospray ionisation interface (LC-ESI-MS) resulted in a 82% and a 78% degradation of oxytocin at pH 3 and a 5% and a 7% degradation at pH 6.5.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    In a glutathione and oxytocin reaction at pH 6.5, LC-UV and LC-ESI-MS measured 5% and 7% degradation of oxytocin.

    In plain wordsIn lab tests at pH 6.5, two chemical methods found that little oxytocin degraded.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin degradation at pH 6.5 by LC-UV and LC-ESI-MS
    Study

    n: not reported in source

    Glutathione and oxytocin reaction mixture
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Measurements

    Oxytocin degradation by LC-UV
    5%
    pH 6.5
    Oxytocin degradation by LC-ESI-MS
    7%
    pH 6.5

    Source sentences

    Summary
    Liquid chromatography coupled to UV (LC-UV) and mass spectrometry via an electrospray ionisation interface (LC-ESI-MS) resulted in a 82% and a 78% degradation of oxytocin at pH 3 and a 5% and a 7% degradation at pH 6.5.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    Capillary electrophoresis with UV detection measured 44% degradation of oxytocin in the glutathione reaction.

    In plain wordsIn lab tests, capillary electrophoresis found that 44% of oxytocin degraded.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin degradation by CE-UV
    Study

    n: not reported in source

    Glutathione and oxytocin reaction mixture
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Measurements

    Oxytocin degradation by CE-UV
    44%
    glutathione reaction

    Source sentences

    Summary
    Capillary electrophoresis employing UV-detection (CE-UV) showed a 44% degradation of oxytocin.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    Near infrared spectroscopy detected newly formed oxytocin-glutathione conjugates after thin layer chromatography separation.

    In plain wordsIn lab tests, near infrared spectroscopy detected new oxytocin-glutathione conjugates.

    Peptide
    Oxytocin
    Outcome
    Not applicableDetection of oxytocin-glutathione conjugates by NIRS
    Study

    n: not reported in source

    Glutathione and oxytocin reaction mixture
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    Nevertheless, NIRS proved to be highly suitable for the detection of newly formed conjugates after separating them on a thin layer chromatography (TLC) plate.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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