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Study · Animal study (in vivo) · mouse · 2008

6 results

Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease.

Kannengiesser K, Maaser C, Heidemann J, Luegering A, Ross M, Brzoska T, Bohm M, Luger TA, Domschke W, Kucharzik T

Inflammatory bowel diseases1 Mar 2008Cited by 45 (Europe PMC)

PMID18092346 (opens in a new tab)DOI10.1002/ibd.20334 (opens in a new tab)PepBankPUB-18092346
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with dextran sodium sulfate colitis, KPV treatment led to earlier recovery and significantly stronger regain of body weight.

    In plain wordsIn mice with colitis, KPV treatment led to earlier recovery and more regain of body weight.

    Peptide
    KPV
    Outcome
    IncreaseBody weight regain in DSS colitis
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Body weight · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the DSS-colitis model, treatment with KPV led to earlier recovery and significantly stronger regain of body weight.
    1 context sentence
    Summary · context
    The anti-inflammatory activity of KPV was analyzed in 2 well-described models of IBD: DSS colitis, and CD45RB(hi) transfer colitis.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with dextran sodium sulfate colitis, KPV treatment significantly reduced inflammatory infiltrates in the colon.

    In plain wordsIn mice with colitis, KPV treatment reduced inflammatory cells in the colon tissue.

    Peptide
    KPV
    Outcome
    DecreaseHistological inflammatory infiltrates in DSS colitis
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Histologically, inflammatory infiltrates were significantly reduced in KPV-treated mice
    1 context sentence
    Summary · context
    The anti-inflammatory activity of KPV was analyzed in 2 well-described models of IBD: DSS colitis, and CD45RB(hi) transfer colitis.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with dextran sodium sulfate colitis, KPV treatment significantly reduced myeloperoxidase activity in colonic tissue.

    In plain wordsIn mice with colitis, KPV treatment lowered a marker of inflammation (MPO activity) in the colon.

    Peptide
    KPV
    Outcome
    DecreaseColonic myeloperoxidase activity in DSS colitis
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    which was confirmed by the significant reduction of MPO activity in colonic tissue after KPV treatment
    1 context sentence
    Summary · context
    The anti-inflammatory activity of KPV was analyzed in 2 well-described models of IBD: DSS colitis, and CD45RB(hi) transfer colitis.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with CD45RB(hi) transfer colitis, KPV treatment led to recovery and regain of body weight.

    In plain wordsIn mice with transfer colitis, KPV treatment led to recovery and regain of body weight.

    Peptide
    KPV
    Outcome
    IncreaseRecovery and body weight regain in transfer colitis
    Study

    mousen: not reported in source

    CD45RB(hi) transfer colitis
    Outcome group
    Body weight · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Supporting these findings, KPV treatment of transfer colitis led to recovery, regain of body weight, and reduced inflammatory changes histologically.
    1 context sentence
    Summary · context
    The anti-inflammatory activity of KPV was analyzed in 2 well-described models of IBD: DSS colitis, and CD45RB(hi) transfer colitis.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with CD45RB(hi) transfer colitis, KPV treatment reduced inflammatory changes in colon histology.

    In plain wordsIn mice with transfer colitis, KPV treatment reduced signs of inflammation in the colon tissue.

    Peptide
    KPV
    Outcome
    DecreaseHistological inflammatory changes in transfer colitis
    Study

    mousen: not reported in source

    CD45RB(hi) transfer colitis
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Supporting these findings, KPV treatment of transfer colitis led to recovery, regain of body weight, and reduced inflammatory changes histologically.
    1 context sentence
    Summary · context
    The anti-inflammatory activity of KPV was analyzed in 2 well-described models of IBD: DSS colitis, and CD45RB(hi) transfer colitis.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with a nonfunctional melanocortin-1 receptor and DSS colitis, KPV treatment rescued all treated animals from death.

    In plain wordsIn mice lacking a working melanocortin-1 receptor and given a colitis-inducing agent, KPV treatment kept all treated animals alive.

    Peptide
    KPV
    Outcome
    DecreaseSurvival of MC1R-nonfunctional mice with DSS colitis
    Study

    mousen: not reported in source

    MC1Re/e mice with DSS colitis
    Outcome group
    Mortality · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In MC1Re/e mice, KPV treatment rescued all animals in the treatment group from death during DSS colitis.
    1 context sentence
    Summary · context
    Furthermore, animals expressing a nonfunctional melanocortin-1 receptor (MC1Re/e) received DSS for induction of colitis and were treated with KPV.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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