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Study · In vitro (cells) · 2008

3 results

A Novel iron-chelating derivative of the neuroprotective peptide NAPVSIPQ shows superior antioxidant and antineurodegenerative capabilities.

Blat D, Weiner L, Youdim MB, Fridkin M

Journal of medicinal chemistry14 Dec 2007Cited by 31 (Europe PMC)

PMID18078312 (opens in a new tab)DOI10.1021/jm070800l (opens in a new tab)PepBankPUB-18078312
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human neuroblastoma cultures, native NAP provided less protection against hydrogen peroxide toxicity than dihydroxamate peptide 3.

    In plain wordsIn cells, native NAP protected less against hydrogen peroxide toxicity than its dihydroxamate derivative.

    Peptide
    Davunetide
    Outcome
    DecreaseProtection against hydrogen peroxide toxicity
    Study

    Humann: not reported in source

    Human neuroblastoma cell cultures exposed to hydrogen peroxide
    Comparator
    Dihydroxamate peptide 3
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, peptide 3 was superior to native NAP in protecting human neuroblastoma cell cultures against the toxicity of hydrogen peroxide.
  2. 02LabIn vitro (cell-free)Activity measurement

    In laboratory experiments, native NAP lacked the hydroxyl radical formation inhibition reported for dihydroxamate peptide 3.

    In plain wordsIn lab tests, native NAP lacked the radical-blocking ability reported for its dihydroxamate derivative.

    Peptide
    Davunetide
    Outcome
    Not applicableInhibition of iron-catalyzed hydroxyl radical formation
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our experiments revealed that the novel dihydroxamate peptide 3 is capable of inhibiting iron-catalyzed hydroxyl radical formation and lipid peroxidation, abilities that are not part of the repertoire of its parent peptide.
  3. 03LabIn vitro (cell-free)Activity measurement

    In laboratory experiments, native NAP lacked the lipid peroxidation inhibition reported for dihydroxamate peptide 3.

    In plain wordsIn lab tests, native NAP lacked the lipid oxidation inhibition reported for its dihydroxamate derivative.

    Peptide
    Davunetide
    Outcome
    Not applicableInhibition of lipid peroxidation
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our experiments revealed that the novel dihydroxamate peptide 3 is capable of inhibiting iron-catalyzed hydroxyl radical formation and lipid peroxidation, abilities that are not part of the repertoire of its parent peptide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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