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Study · Ex vivo tissue · 2008

3 results

The quantitative and functional relation between insulin-like growth factor-I (IGF) and IGF-binding proteins during human osteoarthritis.

Morales TI

Journal of orthopaedic research : official publication of the Orthopaedic Research Society1 Apr 2008Cited by 25 (Europe PMC)

PMID18050312 (opens in a new tab)PMCIDPMC2988493 (opens in a new tab)DOI10.1002/jor.20549 (opens in a new tab)PepBankPUB-18050312
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In human osteoarthritis cartilage, des (1-3) IGF-I stimulated proteoglycan synthesis with maximal effects similar to hrIGF-I.

    In plain wordsIn lab tests, des (1-3) IGF-I increased cartilage proteoglycan production, with a maximum effect similar to hrIGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeMaximal proteoglycan synthesis
    Study

    humann = 10

    Human osteoarthritis cartilage organ cultures
    Comparator
    hrIGF-I
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Mean stimulation
    2.23 fold
    des (1-3) IGF-I maximal effect

    Source sentences

    Summary
    The des (1-3) IGF-I analog (which lacks the three N-terminal amino acids) had similar maximal effects (average 2.23-fold stimulation +/- 0.71, n = 10), but it was more effective in two out of three samples at suboptimal doses.
    1 context sentence
    Summary · context
    Knee or hip OA cartilages were staged for OA by histology. Cartilage slices were either extracted for assays of IGF proteins, or maintained intact as organ cultures. Proteoglycan (PG) metabolism +/- IGFs was measured by use of the (35)S-sulfate precursor.
  2. 02LabEx vivo tissueEfficacy outcome

    In human osteoarthritis cartilage, des (1-3) IGF-I was more effective than hrIGF-I at suboptimal doses in two of three samples.

    In plain wordsIn lab tests, des (1-3) IGF-I increased cartilage proteoglycan production more than hrIGF-I at low doses in some samples.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseProteoglycan synthesis at suboptimal doses
    Study

    humann = 3

    Human osteoarthritis cartilage organ cultures
    Comparator
    hrIGF-I
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The des (1-3) IGF-I analog (which lacks the three N-terminal amino acids) had similar maximal effects (average 2.23-fold stimulation +/- 0.71, n = 10), but it was more effective in two out of three samples at suboptimal doses.
    1 context sentence
    Summary · context
    Knee or hip OA cartilages were staged for OA by histology. Cartilage slices were either extracted for assays of IGF proteins, or maintained intact as organ cultures. Proteoglycan (PG) metabolism +/- IGFs was measured by use of the (35)S-sulfate precursor.
  3. 03LabEx vivo tissueEfficacy outcome

    In human osteoarthritis cartilage, des (1-3) IGF-I had minimal effects on proteoglycan degradation.

    In plain wordsIn lab tests, des (1-3) IGF-I had little effect on cartilage proteoglycan breakdown.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Direction not reportedProteoglycan degradation
    Study

    humann: not reported in source

    Human osteoarthritis cartilage organ cultures
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effect of hrIGF-I, des (1-3) IGF-I, or the B-chain analog on degradation was minimal.
    1 context sentence
    Summary · context
    Knee or hip OA cartilages were staged for OA by histology. Cartilage slices were either extracted for assays of IGF proteins, or maintained intact as organ cultures. Proteoglycan (PG) metabolism +/- IGFs was measured by use of the (35)S-sulfate precursor.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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