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Study · Animal study (in vivo) · 2007

2 results

Comparative study of analgesic potency of ACTH4-10 fragment and its analog semax.

Ivanova DM, Levitskaya NG, Andreeva LA, Kamenskii AA, Myasoedov NF

Bulletin of experimental biology and medicine1 Jan 2007Cited by 2 (Europe PMC)

PMID18018999 (opens in a new tab)DOI10.1007/s10517-007-0002-5 (opens in a new tab)PepBankPUB-18018999
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animal models of nociception, Semax at 0.015 to 0.500 mg/kg decreased pain sensitivity in all experimental models.

    In plain wordsIn animals, Semax lowered pain sensitivity in every test model used.

    Peptide
    Semax
    Outcome
    DecreasePain sensitivity (nociception) in all tested models
    Study

    n: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    0.015-0.500 mg/kgAs given in this study.

    Source sentences

    Summary
    Semax (0.015-0.500 mg/kg) decreased pain sensitivity in all experimental models.
    1 context sentence
    Summary · context
    The effects of ACTH4-10 fragment and its analog semax on nociception were examined on various animal models.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In animal models of nociception, Semax had greater analgesic potency than ACTH4-10 after peripheral injection.

    In plain wordsIn animals, Semax relieved pain more strongly than ACTH4-10 after injection.

    Peptide
    Semax
    Outcome
    IncreaseAnalgesic potency of Semax versus ACTH4-10
    Study

    n: not reported in source

    Comparator
    ACTH4-10
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · peripheral injectionAs given in this study.

    Source sentences

    Summary
    Hence, the substitution of three C-terminal amino acid residues in ACTH4-10 for Pro-Gly-Pro sequence augmented the analgesic potency of the peptide after its peripheral injection.
    1 context sentence
    Summary · context
    The effects of ACTH4-10 fragment and its analog semax on nociception were examined on various animal models.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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