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Study · In vitro (cells) · 2008

7 results

Oxytocin increases 5alpha-reductase activity of human prostate epithelial cells, but not stromal cells.

Assinder SJ

The Prostate1 Feb 2008Cited by 9 (Europe PMC)

PMID18008328 (opens in a new tab)DOI10.1002/pros.20671 (opens in a new tab)PepBankPUB-18008328
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human prostate epithelial cells, oxytocin increased total 5-alpha-reductase activity.

    In plain wordsIn cells, oxytocin raised 5-alpha-reductase activity in prostate epithelial cells.

    Peptide
    Oxytocin
    Outcome
    IncreaseTotal 5-alpha-reductase activity in PrEC
    Study

    humann: not reported in source

    Human prostate epithelial cells (PrEC) and stromal cells (PrSC)
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · 24 hrAs given in this study (human).

    Source sentences

    Summary
    Oxytocin significantly increased the total 5-alpha-reductase activity of PrEC but not of PrSC.
    1 context sentence
    Summary · context
    Cell cultures were incubated with oxytocin, or oxytocin plus a specific oxytocin antagonist for 24 hr, and conversion of (3)H-Testosterone to dihydrotestosterone used to estimate total 5-alpha-reductase activity and to determine activity of both type I and type II isoenzymes.
  2. 02LabIn vitro (cells)Mechanism

    In human prostate stromal cells, oxytocin did not significantly change total 5-alpha-reductase activity.

    In plain wordsIn cells, oxytocin did not change 5-alpha-reductase activity in prostate stromal cells.

    Peptide
    Oxytocin
    Outcome
    No significant changeTotal 5-alpha-reductase activity in PrSC
    Study

    humann: not reported in source

    Human prostate epithelial cells (PrEC) and stromal cells (PrSC)
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · 24 hrAs given in this study (human).

    Source sentences

    Summary
    Oxytocin significantly increased the total 5-alpha-reductase activity of PrEC but not of PrSC.
    1 context sentence
    Summary · context
    Cell cultures were incubated with oxytocin, or oxytocin plus a specific oxytocin antagonist for 24 hr, and conversion of (3)H-Testosterone to dihydrotestosterone used to estimate total 5-alpha-reductase activity and to determine activity of both type I and type II isoenzymes.
  3. 03LabIn vitro (cells)Mechanism

    In human prostate epithelial cells, oxytocin increased 5-alpha-reductase I gene expression.

    In plain wordsIn cells, oxytocin raised the gene expression of 5-alpha-reductase I in prostate epithelial cells.

    Peptide
    Oxytocin
    Outcome
    Increase5-alpha-reductase I expression in PrEC
    Study

    humann: not reported in source

    Human prostate epithelial cells (PrEC) and stromal cells (PrSC)
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · 24 hrAs given in this study (human).

    Source sentences

    Summary
    5-alpha-Reductase I gene expression and enzyme activity were also increased (P<0.05) in PrEC by oxytocin.
    1 context sentence
    Summary · context
    Cell cultures were incubated with oxytocin, or oxytocin plus a specific oxytocin antagonist for 24 hr, and conversion of (3)H-Testosterone to dihydrotestosterone used to estimate total 5-alpha-reductase activity and to determine activity of both type I and type II isoenzymes.
  4. 04LabIn vitro (cells)Mechanism

    In human prostate epithelial cells, oxytocin increased 5-alpha-reductase I enzyme activity.

    In plain wordsIn cells, oxytocin raised 5-alpha-reductase I enzyme activity in prostate epithelial cells.

    Peptide
    Oxytocin
    Outcome
    Increase5-alpha-reductase I activity in PrEC
    Study

    humann: not reported in source

    Human prostate epithelial cells (PrEC) and stromal cells (PrSC)
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · 24 hrAs given in this study (human).

    Source sentences

    Summary
    5-alpha-Reductase I gene expression and enzyme activity were also increased (P<0.05) in PrEC by oxytocin.
    1 context sentence
    Summary · context
    Cell cultures were incubated with oxytocin, or oxytocin plus a specific oxytocin antagonist for 24 hr, and conversion of (3)H-Testosterone to dihydrotestosterone used to estimate total 5-alpha-reductase activity and to determine activity of both type I and type II isoenzymes.
  5. 05LabIn vitro (cells)Mechanism

    In human prostate epithelial cells, oxytocin increased 5-alpha-reductase type II activity.

    In plain wordsIn cells, oxytocin raised 5-alpha-reductase type II activity in prostate epithelial cells.

    Peptide
    Oxytocin
    Outcome
    Increase5-alpha-reductase II activity in PrEC
    Study

    humann: not reported in source

    Human prostate epithelial cells (PrEC) and stromal cells (PrSC)
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · 24 hrAs given in this study (human).

    Source sentences

    Summary
    Oxytocin significantly increased type II activity, but not expression, in PrEC.
    1 context sentence
    Summary · context
    Cell cultures were incubated with oxytocin, or oxytocin plus a specific oxytocin antagonist for 24 hr, and conversion of (3)H-Testosterone to dihydrotestosterone used to estimate total 5-alpha-reductase activity and to determine activity of both type I and type II isoenzymes.
  6. 06LabIn vitro (cells)Mechanism

    In human prostate epithelial cells, oxytocin did not significantly change 5-alpha-reductase type II expression.

    In plain wordsIn cells, oxytocin did not change 5-alpha-reductase type II expression in prostate epithelial cells.

    Peptide
    Oxytocin
    Outcome
    No significant change5-alpha-reductase II expression in PrEC
    Study

    humann: not reported in source

    Human prostate epithelial cells (PrEC) and stromal cells (PrSC)
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · 24 hrAs given in this study (human).

    Source sentences

    Summary
    Oxytocin significantly increased type II activity, but not expression, in PrEC.
    1 context sentence
    Summary · context
    Cell cultures were incubated with oxytocin, or oxytocin plus a specific oxytocin antagonist for 24 hr, and conversion of (3)H-Testosterone to dihydrotestosterone used to estimate total 5-alpha-reductase activity and to determine activity of both type I and type II isoenzymes.
  7. 07LabIn vitro (cells)Mechanism

    In human prostate stromal cells, oxytocin did not significantly affect 5-alpha-reductase expression.

    In plain wordsIn cells, oxytocin did not change 5-alpha-reductase expression in prostate stromal cells.

    Peptide
    Oxytocin
    Outcome
    No significant change5-alpha-reductase expression in PrSC
    Study

    humann: not reported in source

    Human prostate epithelial cells (PrEC) and stromal cells (PrSC)
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · 24 hrAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not significantly affect 5-alpha-reductase activity or expression in PrSC.
    1 context sentence
    Summary · context
    Cell cultures were incubated with oxytocin, or oxytocin plus a specific oxytocin antagonist for 24 hr, and conversion of (3)H-Testosterone to dihydrotestosterone used to estimate total 5-alpha-reductase activity and to determine activity of both type I and type II isoenzymes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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