GH-releasing peptide-2 administration prevents liver inflammatory response in endotoxemia.

Granado M, Martín AI, López-Menduiña M, López-Calderón A, Villanúa MA

American journal of physiology. Endocrinology and metabolism6 Nov 2007Cited by 32 (Europe PMC)

PMID17986630DOI10.1152/ajpendo.00308.2007PepBankPUB-17986630

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In Wistar rats given LPS, GHRP‑2 attenuated the LPS-induced increase in serum transaminases.
In plain wordsIn rats given a bacterial toxin, GHRP‑2 reduced the rise in blood liver enzymes.
Peptide
GHRP-2
Outcome
DecreaseSerum transaminases in LPS-treated rats
Study
ratn: not reported in source
LPS-induced endotoxemia
Outcome group
Liver fat and liver function · Liver
Studied dose
100 microg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
GHRP-2 administration attenuated the effects of LPS on transaminases, nitrites/nitrates, TNF-alpha, and IGF-I in vivo.
2 context sentences(design, population, supporting numbers)
Summary · context
LPS increased serum levels of transaminases and nitrites/nitrates.
Summary · context
Wistar rats were simultaneously injected (ip) with LPS (1 mg/kg) and/or GHRP-2 (100 microg/kg).
Report a problemFND-1798663001
02AnimalAnimal study (in vivo)Mechanism
In Wistar rats given LPS, GHRP‑2 attenuated the LPS-induced increase in circulating nitrites/nitrates.
In plain wordsIn rats given a bacterial toxin, GHRP‑2 reduced the rise in blood nitric oxide products.
Peptide
GHRP-2
Outcome
DecreaseCirculating nitrites/nitrates in LPS-treated rats
Study
ratn: not reported in source
LPS-induced endotoxemia
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
100 microg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
GHRP-2 administration attenuated the effects of LPS on transaminases, nitrites/nitrates, TNF-alpha, and IGF-I in vivo.
2 context sentences(design, population, supporting numbers)
Summary · context
LPS increased serum levels of transaminases and nitrites/nitrates.
Summary · context
Wistar rats were simultaneously injected (ip) with LPS (1 mg/kg) and/or GHRP-2 (100 microg/kg).
Report a problemFND-1798663002
03AnimalAnimal study (in vivo)Mechanism
In Wistar rats given LPS, GHRP‑2 attenuated the LPS-induced increase in hepatic TNF-alpha mRNA.
In plain wordsIn rats given a bacterial toxin, GHRP‑2 reduced the rise in liver TNF-alpha gene activity.
Peptide
GHRP-2
Outcome
DecreaseHepatic TNF-alpha mRNA in LPS-treated rats
Study
ratn: not reported in source
LPS-induced endotoxemia
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
100 microg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
GHRP-2 administration attenuated the effects of LPS on transaminases, nitrites/nitrates, TNF-alpha, and IGF-I in vivo.
2 context sentences(design, population, supporting numbers)
Summary · context
Moreover, LPS increased hepatic TNF-alpha and decreased hepatic IGF-I mRNAs.
Summary · context
Wistar rats were simultaneously injected (ip) with LPS (1 mg/kg) and/or GHRP-2 (100 microg/kg).
Report a problemFND-1798663003
04AnimalAnimal study (in vivo)Mechanism
In Wistar rats given LPS, GHRP‑2 attenuated the LPS-induced decrease in hepatic IGF-I mRNA.
In plain wordsIn rats given a bacterial toxin, GHRP‑2 reduced the fall in liver IGF-I gene activity.
Peptide
GHRP-2
Outcome
IncreaseHepatic IGF-I mRNA in LPS-treated rats
Study
ratn: not reported in source
LPS-induced endotoxemia
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
100 microg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
GHRP-2 administration attenuated the effects of LPS on transaminases, nitrites/nitrates, TNF-alpha, and IGF-I in vivo.
2 context sentences(design, population, supporting numbers)
Summary · context
Moreover, LPS increased hepatic TNF-alpha and decreased hepatic IGF-I mRNAs.
Summary · context
Wistar rats were simultaneously injected (ip) with LPS (1 mg/kg) and/or GHRP-2 (100 microg/kg).
Report a problemFND-1798663004
05LabIn vitro (cells)Efficacy outcome
In cocultures of hepatocytes and nonparenchymal cells, GHRP‑2 prevented the endotoxin-induced increase in transaminases.
In plain wordsIn lab-grown liver cell mixtures, GHRP‑2 prevented the rise in liver enzymes caused by a bacterial toxin.
Peptide
GHRP-2
Outcome
DecreaseEndotoxin-induced transaminase increase in cocultures
Study
n: not reported in source
cocultures of hepatocytes and nonparenchymal cells
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
The ghrelin receptor agonist prevented an endotoxin-induced increase in transaminases and nitrite/nitrate release as well as in TNF-alpha mRNA and increased IGF-I mRNA from cocultures of hepatocytes and nonparenchymal cells, but not from monocultures.
1 context sentence(design, population, supporting numbers)
Summary · context
To elucidate whether GHRP-2 is acting directly on the liver, cocultures of hepatocytes and nonparenchymal cells and monocultures of isolated hepatocytes were incubated with LPS and GHRP-2.
Report a problemFND-1798663005
06LabIn vitro (cells)Mechanism
In cocultures of hepatocytes and nonparenchymal cells, GHRP‑2 prevented the endotoxin-induced increase in nitrite/nitrate release.
In plain wordsIn lab-grown liver cell mixtures, GHRP‑2 prevented the rise in nitric oxide products caused by a bacterial toxin.
Peptide
GHRP-2
Outcome
DecreaseEndotoxin-induced nitrite/nitrate release in cocultures
Study
n: not reported in source
cocultures of hepatocytes and nonparenchymal cells
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
The ghrelin receptor agonist prevented an endotoxin-induced increase in transaminases and nitrite/nitrate release as well as in TNF-alpha mRNA and increased IGF-I mRNA from cocultures of hepatocytes and nonparenchymal cells, but not from monocultures.
1 context sentence(design, population, supporting numbers)
Summary · context
To elucidate whether GHRP-2 is acting directly on the liver, cocultures of hepatocytes and nonparenchymal cells and monocultures of isolated hepatocytes were incubated with LPS and GHRP-2.
Report a problemFND-1798663006
07LabIn vitro (cells)Mechanism
In cocultures of hepatocytes and nonparenchymal cells, GHRP‑2 prevented the endotoxin-induced increase in TNF-alpha mRNA.
In plain wordsIn lab-grown liver cell mixtures, GHRP‑2 prevented the rise in TNF-alpha gene activity caused by a bacterial toxin.
Peptide
GHRP-2
Outcome
DecreaseEndotoxin-induced TNF-alpha mRNA in cocultures
Study
n: not reported in source
cocultures of hepatocytes and nonparenchymal cells
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
The ghrelin receptor agonist prevented an endotoxin-induced increase in transaminases and nitrite/nitrate release as well as in TNF-alpha mRNA and increased IGF-I mRNA from cocultures of hepatocytes and nonparenchymal cells, but not from monocultures.
1 context sentence(design, population, supporting numbers)
Summary · context
To elucidate whether GHRP-2 is acting directly on the liver, cocultures of hepatocytes and nonparenchymal cells and monocultures of isolated hepatocytes were incubated with LPS and GHRP-2.
Report a problemFND-1798663007
08LabIn vitro (cells)Mechanism
In cocultures of hepatocytes and nonparenchymal cells, GHRP‑2 increased IGF-I mRNA.
In plain wordsIn lab-grown liver cell mixtures, GHRP‑2 raised IGF-I gene activity.
Peptide
GHRP-2
Outcome
IncreaseIGF-I mRNA in cocultures
Study
n: not reported in source
cocultures of hepatocytes and nonparenchymal cells
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
The ghrelin receptor agonist prevented an endotoxin-induced increase in transaminases and nitrite/nitrate release as well as in TNF-alpha mRNA and increased IGF-I mRNA from cocultures of hepatocytes and nonparenchymal cells, but not from monocultures.
1 context sentence(design, population, supporting numbers)
Summary · context
To elucidate whether GHRP-2 is acting directly on the liver, cocultures of hepatocytes and nonparenchymal cells and monocultures of isolated hepatocytes were incubated with LPS and GHRP-2.
Report a problemFND-1798663008
09LabIn vitro (cells)Mechanism
In monocultures of isolated hepatocytes, GHRP‑2 did not produce the effects seen in cocultures (transaminases, nitrite/nitrate, TNF-alpha mRNA, IGF-I mRNA).
In plain wordsIn lab-grown liver cells alone, GHRP‑2 did not show the protective effects seen in mixed liver cell cultures.
Peptide
GHRP-2
Outcome
No significant changeGHRP-2 effects on endotoxin-induced changes in hepatocyte monocultures
Study
n: not reported in source
monocultures of isolated hepatocytes
Outcome group
Inflammation markers · Liver
Studied dose
Dose not stated
Source sentences
Summary
The ghrelin receptor agonist prevented an endotoxin-induced increase in transaminases and nitrite/nitrate release as well as in TNF-alpha mRNA and increased IGF-I mRNA from cocultures of hepatocytes and nonparenchymal cells, but not from monocultures.
1 context sentence(design, population, supporting numbers)
Summary · context
To elucidate whether GHRP-2 is acting directly on the liver, cocultures of hepatocytes and nonparenchymal cells and monocultures of isolated hepatocytes were incubated with LPS and GHRP-2.
Report a problemFND-1798663009

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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