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Study · Animal study (in vivo) · rat · 2007

5 results

Bremelanotide: an overview of preclinical CNS effects on female sexual function.

Pfaus J, Giuliano F, Gelez H

The journal of sexual medicine1 Nov 2007Cited by 65 (Europe PMC)

PMID17958619 (opens in a new tab)DOI10.1111/j.1743-6109.2007.00610.x (opens in a new tab)PepBankPUB-17958619
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized, hormone-primed female rats, bremelanotide increased solicitation after subcutaneous dosing or infusion into the lateral ventricles or medial preoptic area.

    In plain wordsIn female rats, bremelanotide strongly increased solicitation behavior after injection under the skin or infusion into certain brain areas.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    IncreaseSolicitation behavior
    Study

    ratn: not reported in source

    ovariectomized, hormone-primed female rats
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous, intracerebroventricular, or medial preoptic area infusionAs given in this study (rat).

    Source sentences

    Summary
    Bremelanotide dramatically and selectively increased measures of solicitation in female rats, without altering pacing or lordosis, following both peripheral (subcutaneous) administration or infusions directly into the lateral ventricles or medial preoptic area (mPOA)
    1 context sentence
    Summary · context
    Using a model that allows ovariectomized, hormone-primed female rats to control the timing of sexual encounters with males, we tested the ability of bremelanotide to increase appetitive (proceptive) and/or consummatory sexual behaviors.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, infusion of bremelanotide into the ventromedial hypothalamus did not increase solicitation.

    In plain wordsIn female rats, bremelanotide infused into the ventromedial hypothalamus did not increase solicitation behavior.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    No significant changeSolicitation after ventromedial hypothalamus infusion
    Study

    ratn: not reported in source

    ovariectomized, hormone-primed female rats
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · ventromedial hypothalamus infusionAs given in this study (rat).

    Source sentences

    Summary
    but not the ventromedial hypothalamus.
    1 context sentence
    Summary · context
    Using a model that allows ovariectomized, hormone-primed female rats to control the timing of sexual encounters with males, we tested the ability of bremelanotide to increase appetitive (proceptive) and/or consummatory sexual behaviors.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, bremelanotide did not alter pacing.

    In plain wordsIn female rats, bremelanotide did not change pacing behavior.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    No significant changePacing
    Study

    ratn: not reported in source

    ovariectomized, hormone-primed female rats
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous, intracerebroventricular, or medial preoptic area infusionAs given in this study (rat).

    Source sentences

    Summary
    without altering pacing or lordosis, following both peripheral (subcutaneous) administration or infusions directly into the lateral ventricles or medial preoptic area (mPOA), but not the ventromedial hypothalamus.
    1 context sentence
    Summary · context
    Using a model that allows ovariectomized, hormone-primed female rats to control the timing of sexual encounters with males, we tested the ability of bremelanotide to increase appetitive (proceptive) and/or consummatory sexual behaviors.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, bremelanotide did not alter lordosis.

    In plain wordsIn female rats, bremelanotide did not change lordosis behavior.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    No significant changeLordosis
    Study

    ratn: not reported in source

    ovariectomized, hormone-primed female rats
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous, intracerebroventricular, or medial preoptic area infusionAs given in this study (rat).

    Source sentences

    Summary
    without altering pacing or lordosis, following both peripheral (subcutaneous) administration or infusions directly into the lateral ventricles or medial preoptic area (mPOA), but not the ventromedial hypothalamus.
    1 context sentence
    Summary · context
    Using a model that allows ovariectomized, hormone-primed female rats to control the timing of sexual encounters with males, we tested the ability of bremelanotide to increase appetitive (proceptive) and/or consummatory sexual behaviors.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In female rats, peripheral bremelanotide activated the medial preoptic area and other hypothalamic and limbic regions involved in sexual behavior.

    In plain wordsIn female rats, bremelanotide given outside the brain activated brain regions involved in sexual behavior.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    IncreaseBrain activation after peripheral dosing
    Study

    ratn: not reported in source

    ovariectomized, hormone-primed female rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · peripheralAs given in this study (rat).

    Source sentences

    Summary
    Peripheral administration of bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior
    1 context sentence
    Summary · context
    Using a model that allows ovariectomized, hormone-primed female rats to control the timing of sexual encounters with males, we tested the ability of bremelanotide to increase appetitive (proceptive) and/or consummatory sexual behaviors.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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