In rats with metaphit-induced audiogenic seizures, valproate combined with DSIP was more effective than the single drugs, especially during 4 h after administration.
In plain wordsIn rats with induced seizures, valproate plus DSIP worked better than either drug alone during the first hours.
- Outcome
- IncreaseSeizure control with valproate plus DSIP versus either drug alone
- Study
ratn: not reported in source
Wistar rats, metaphit audiogenic seizure model- Comparator
- Valproate alone or DSIP alone
- Outcome group
- Neuroprotection · Nervous system and cognition
Source sentences
Combined treatment of metaphit-induced seizures with valproate and DSIP was more effective than drugs alone especially during 4 h after administration.
1 context sentence(design, population, supporting numbers)
For the purpose of the study, valproate in the doses of 50 or 75 mg/kg and DSIP (1.0 mg/kg) was i.p. injected either alone or in combination to adult Wistar male rats with fully developed metaphit seizures after eight audiogenic testing.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).