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Study · Animal study (in vivo) · rat · 2007

4 results

Effects of intranasal administration of epitalon on neuron activity in the rat neocortex.

Sibarov DA, Vol'nova AB, Frolov DS, Nozdrachev AD

Neuroscience and behavioral physiology1 Nov 2007Cited by 1 (Europe PMC)

PMID17955380 (opens in a new tab)DOI10.1007/s11055-007-0095-3 (opens in a new tab)PepBankPUB-17955380
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, intranasal epitalon significantly increased the discharge frequency of cortical neurons by a factor of 2-2.5 within several minutes.

    In plain wordsIn rats, epitalon given through the nose raised the firing rate of brain cortex neurons by 2 to 2.5 times within minutes.

    Peptide
    Epitalon
    Outcome
    IncreaseDischarge frequency of cortical neurons
    Study

    ratn: not reported in source

    Urethane-anesthetized male Wistar rats
    Comparator
    Pre-administration spontaneous activity
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    30 ng per animal · intranasalAs given in this study (rat).

    Measurements

    Discharge frequency increase
    2 to 2.5 fold
    cortical neurons

    Source sentences

    Summary
    Significant activation of neuron activity was seen several minutes after dosage, with an increase (by factors of 2-2.5) in discharge frequency.
    1 context sentence
    Summary · context
    Studies were performed using male Wistar rats anesthetized with urethane (1 g/kg).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In some experiments in rats, the effect of epitalon on neuron discharge frequency was multiphasic, with a first peak at 5-7 min followed by peaks at 11-12 and 17-18 min.

    In plain wordsIn some rats, epitalon raised neuron firing in several waves, with peaks at 5-7, 11-12 and 17-18 minutes.

    Peptide
    Epitalon
    Outcome
    MixedTime course of neuron activity
    Study

    ratn: not reported in source

    Urethane-anesthetized male Wistar rats
    Comparator
    Pre-administration spontaneous activity
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    30 ng per animal · intranasalAs given in this study (rat).

    Measurements

    First peak time
    5 to 7 min
    neuron discharge frequency
    Second peak time
    11 to 12 min
    neuron discharge frequency
    Third peak time
    17 to 18 min
    neuron discharge frequency

    Source sentences

    Summary
    In some experiments, the effect of epitalon was multiphasic. The first peak of increased neuron discharge frequency at 5-7 min was followed by peaks at 11-12 and 17-18 min.
    1 context sentence
    Summary · context
    Studies were performed using male Wistar rats anesthetized with urethane (1 g/kg).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, the rise in discharge frequency after intranasal epitalon came from neurons that were already active and from recruitment of previously silent neurons.

    In plain wordsIn rats, the higher firing rate came from neurons that were already active and from neurons that had been silent.

    Peptide
    Epitalon
    Outcome
    IncreaseRecruitment of silent neurons
    Study

    ratn: not reported in source

    Urethane-anesthetized male Wistar rats
    Comparator
    Pre-administration spontaneous activity
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    30 ng per animal · intranasalAs given in this study (rat).

    Source sentences

    Summary
    The increase in discharge frequency occurred because of an increase in the discharge frequency of neurons which were already active and the recruitment of previously silent neurons.
    1 context sentence
    Summary · context
    Studies were performed using male Wistar rats anesthetized with urethane (1 g/kg).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, at least the first peak of increased neuron activity after epitalon was associated with direct action of the peptide on cortical cells.

    In plain wordsIn rats, at least the first rise in neuron activity was linked to a direct action of epitalon on brain cortex cells.

    Peptide
    Epitalon
    Outcome
    Not applicableDirect action on cortical cells
    Study

    ratn: not reported in source

    Urethane-anesthetized male Wistar rats
    Comparator
    Pre-administration spontaneous activity
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    30 ng per animal · intranasalAs given in this study (rat).

    Source sentences

    Summary
    At least the first peak of increased neuron activity following exposure to epitalon was found to be associated with the direct action of the peptide on cortical cells.
    1 context sentence
    Summary · context
    Studies were performed using male Wistar rats anesthetized with urethane (1 g/kg).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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