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Study · Animal study (in vivo) · mouse and rat · 2007

4 results

Thermogenesis activated by central melanocortin signaling is dependent on neurons in the rostral raphe pallidus (rRPa) area.

Fan W, Morrison SF, Cao WH, Yu P

Brain research6 Apr 2007Cited by 39 (Europe PMC)

PMID17935700 (opens in a new tab)DOI10.1016/j.brainres.2007.04.006 (opens in a new tab)PepBankPUB-17935700
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In anesthetized rats, intracerebroventricular melanotan II 1 nmol increased sympathetic nerve activity to interscapular brown adipose tissue.

    In plain wordsIn rats, melanotan II given into the brain increased nerve activity to brown fat.

    Peptide
    Melanotan II
    Outcome
    IncreaseIBAT sympathetic nerve activity
    Study

    ratn: not reported in source

    urethane-chloralose-anesthetized rats
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    1 nmol · intracerebroventricularAs given in this study (rat).

    Measurements

    IBAT SNA change
    741 % of control
    rat, icv MTII 1 nmol

    Source sentences

    Summary
    Icv injection of MTII (1 nmol) significantly increased rat IBAT SNA (+741% of control).
    1 context sentence
    Summary · context
    we studied the effects of inhibition of the activity of neurons in the rRPa area on the sympathetic nerve activity (SNA) to IBAT evoked by lateral ventricular injection of the melanocortin 3/4 receptor (MC3/4R) agonist, MTII, in urethane-chloralose-anesthetized rats and the effects on O(2) consumpti…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In conscious mice, third ventricular melanotan II 1 nmol increased oxygen consumption by 45% compared with saline.

    In plain wordsIn mice, melanotan II given into the brain raised oxygen use more than saline.

    Peptide
    Melanotan II
    Outcome
    IncreaseO2 consumption after third ventricular MTII
    Study

    mousen: not reported in source

    conscious C57BL/6J mice
    Comparator
    Saline
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1 nmol · third ventricular injectionAs given in this study (mouse).

    Measurements

    O2 consumption increase
    45%
    third ventricular injection vs saline

    Source sentences

    Summary
    Both third and fourth ventricular injections of MTII (1 nmol) significantly increased O(2) consumption in conscious C57BL/6J mice (45% higher than that of saline control for third ventricular injection and 44% higher than that of saline control for fourth ventricular injection).
    1 context sentence
    Summary · context
    we studied the effects of inhibition of the activity of neurons in the rRPa area on the sympathetic nerve activity (SNA) to IBAT evoked by lateral ventricular injection of the melanocortin 3/4 receptor (MC3/4R) agonist, MTII, in urethane-chloralose-anesthetized rats and the effects on O(2) consumpti…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In conscious mice, fourth ventricular melanotan II 1 nmol increased oxygen consumption by 44% compared with saline.

    In plain wordsIn mice, melanotan II given into a brain ventricle raised oxygen use more than saline.

    Peptide
    Melanotan II
    Outcome
    IncreaseO2 consumption after fourth ventricular MTII
    Study

    mousen: not reported in source

    conscious C57BL/6J mice
    Comparator
    Saline
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1 nmol · fourth ventricular injectionAs given in this study (mouse).

    Measurements

    O2 consumption increase
    44%
    fourth ventricular injection vs saline

    Source sentences

    Summary
    Both third and fourth ventricular injections of MTII (1 nmol) significantly increased O(2) consumption in conscious C57BL/6J mice (45% higher than that of saline control for third ventricular injection and 44% higher than that of saline control for fourth ventricular injection).
    1 context sentence
    Summary · context
    we studied the effects of inhibition of the activity of neurons in the rRPa area on the sympathetic nerve activity (SNA) to IBAT evoked by lateral ventricular injection of the melanocortin 3/4 receptor (MC3/4R) agonist, MTII, in urethane-chloralose-anesthetized rats and the effects on O(2) consumpti…

Studies that did not test the peptide alone1

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 04AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In rats and mice, inhibiting rRPa neurons with glycine or muscimol reversed the increases in IBAT sympathetic nerve activity and oxygen consumption that melanotan II caused.

    In plain wordsIn rats and mice, blocking a brainstem area undid the effects of melanotan II on brown fat nerve activity and oxygen use.

    Peptide
    Melanotan II
    Outcome
    DecreaseReversal of MTII-induced IBAT SNA and O2 consumption by rRPa inhibition
    Study

    ratn: not reported in source

    rats and C57BL/6J mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    The increases in IBAT SNA and in O(2) consumption were reversed by inhibition of neurons in the rRPa and adjacent area with microinjections of glycine or muscimol into rRPa.
    1 context sentence
    Summary · context
    we studied the effects of inhibition of the activity of neurons in the rRPa area on the sympathetic nerve activity (SNA) to IBAT evoked by lateral ventricular injection of the melanocortin 3/4 receptor (MC3/4R) agonist, MTII, in urethane-chloralose-anesthetized rats and the effects on O(2) consumpti…

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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