Thymosin alpha 1 improves severe acute pancreatitis in rats via regulation of peripheral T cell number and cytokine serum level.

Yao W, Zhu Q, Yuan Y, Qiao M, Zhang Y, Zhai Z

Journal of gastroenterology and hepatology1 Nov 2007Cited by 18 (Europe PMC)

PMID17914961DOI10.1111/j.1440-1746.2006.04699.xPepBankPUB-17914961

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with severe acute pancreatitis, thymosin alpha‑1 did not significantly change serum amylase and lipase.
In plain wordsIn rats with severe pancreatitis, thymosin alpha‑1 did not change blood amylase and lipase levels.
Peptide
Thymosin alpha-1
Outcome
No significant changeSerum amylase and lipase
Study
ratn = 72
sodium taurocholate-induced severe acute pancreatitis (SAP)
Comparator
SAP group
Outcome group
Organ injury · Gastrointestinal
Studied dose
100 microg/kg · subcutaneous · 2 doses, at 0 and 2 hAs given in this study (rat).
Source sentences
Summary
There was no significant change in the serum amylase and lipase levels after TA1 administration.
2 context sentences(design, population, supporting numbers)
Summary · context
Healthy Sprague-Dawley rats (n = 72) were randomly divided into four groups: control group, SAP group, and two TA1 treated groups.
Summary · context
SAP was induced by injection of 5% sterile sodium taurocholate into the biliopancreatic duct (BPD), after which TA1 was given subcutaneously at 0 and 2 h at a dose of 100 microg/kg.
Report a problemFND-1791496101
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with severe acute pancreatitis, thymosin alpha‑1 significantly reduced serum IL-1beta.
In plain wordsIn rats with severe pancreatitis, thymosin alpha‑1 lowered blood levels of the inflammation signal IL-1beta.
Peptide
Thymosin alpha-1
Outcome
DecreaseSerum IL-1beta
Study
ratn = 72
sodium taurocholate-induced severe acute pancreatitis (SAP)
Comparator
SAP group
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
100 microg/kg · subcutaneous · 2 doses, at 0 and 2 hAs given in this study (rat).
Source sentences
Summary
Levels of serum IL-1beta, TNF-alpha and pancreatic wet/dry weight ratio were significantly reduced after TA1-treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Healthy Sprague-Dawley rats (n = 72) were randomly divided into four groups: control group, SAP group, and two TA1 treated groups.
Summary · context
SAP was induced by injection of 5% sterile sodium taurocholate into the biliopancreatic duct (BPD), after which TA1 was given subcutaneously at 0 and 2 h at a dose of 100 microg/kg.
Report a problemFND-1791496102
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with severe acute pancreatitis, thymosin alpha‑1 significantly reduced serum TNF-alpha.
In plain wordsIn rats with severe pancreatitis, thymosin alpha‑1 lowered blood levels of the inflammation signal TNF-alpha.
Peptide
Thymosin alpha-1
Outcome
DecreaseSerum TNF-alpha
Study
ratn = 72
sodium taurocholate-induced severe acute pancreatitis (SAP)
Comparator
SAP group
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
100 microg/kg · subcutaneous · 2 doses, at 0 and 2 hAs given in this study (rat).
Source sentences
Summary
Levels of serum IL-1beta, TNF-alpha and pancreatic wet/dry weight ratio were significantly reduced after TA1-treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Healthy Sprague-Dawley rats (n = 72) were randomly divided into four groups: control group, SAP group, and two TA1 treated groups.
Summary · context
SAP was induced by injection of 5% sterile sodium taurocholate into the biliopancreatic duct (BPD), after which TA1 was given subcutaneously at 0 and 2 h at a dose of 100 microg/kg.
Report a problemFND-1791496103
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with severe acute pancreatitis, thymosin alpha‑1 significantly reduced the pancreatic wet/dry weight ratio.
In plain wordsIn rats with severe pancreatitis, thymosin alpha‑1 reduced pancreatic swelling, measured by the wet/dry weight ratio.
Peptide
Thymosin alpha-1
Outcome
DecreasePancreatic wet/dry weight ratio
Study
ratn = 72
sodium taurocholate-induced severe acute pancreatitis (SAP)
Comparator
SAP group
Outcome group
Organ injury · Gastrointestinal
Studied dose
100 microg/kg · subcutaneous · 2 doses, at 0 and 2 hAs given in this study (rat).
Source sentences
Summary
Levels of serum IL-1beta, TNF-alpha and pancreatic wet/dry weight ratio were significantly reduced after TA1-treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Healthy Sprague-Dawley rats (n = 72) were randomly divided into four groups: control group, SAP group, and two TA1 treated groups.
Summary · context
SAP was induced by injection of 5% sterile sodium taurocholate into the biliopancreatic duct (BPD), after which TA1 was given subcutaneously at 0 and 2 h at a dose of 100 microg/kg.
Report a problemFND-1791496104
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with severe acute pancreatitis, thymosin alpha‑1 significantly balanced the CD3/CD4+/CD8+ T cell percentages in peripheral blood mononuclear cells.
In plain wordsIn rats with severe pancreatitis, thymosin alpha‑1 brought the balance of blood T cell types closer to normal.
Peptide
Thymosin alpha-1
Outcome
MixedCD3/CD4+/CD8+ T cell balance in PBMC
Study
ratn = 72
sodium taurocholate-induced severe acute pancreatitis (SAP)
Comparator
SAP group
Outcome group
Immune response · Immune and inflammation
Studied dose
100 microg/kg · subcutaneous · 2 doses, at 0 and 2 hAs given in this study (rat).
Source sentences
Summary
Application of TA1 significantly balanced CD3/CD4+/CD8+ T cells of PBMC and improved histological scores and the survival rate.
2 context sentences(design, population, supporting numbers)
Summary · context
Healthy Sprague-Dawley rats (n = 72) were randomly divided into four groups: control group, SAP group, and two TA1 treated groups.
Summary · context
SAP was induced by injection of 5% sterile sodium taurocholate into the biliopancreatic duct (BPD), after which TA1 was given subcutaneously at 0 and 2 h at a dose of 100 microg/kg.
Report a problemFND-1791496105
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with severe acute pancreatitis, thymosin alpha‑1 improved histological scores.
In plain wordsIn rats with severe pancreatitis, thymosin alpha‑1 improved tissue damage scores of the pancreas.
Peptide
Thymosin alpha-1
Outcome
Not applicableHistological score
Study
ratn = 72
sodium taurocholate-induced severe acute pancreatitis (SAP)
Comparator
SAP group
Outcome group
Organ injury · Gastrointestinal
Studied dose
100 microg/kg · subcutaneous · 2 doses, at 0 and 2 hAs given in this study (rat).
Source sentences
Summary
Application of TA1 significantly balanced CD3/CD4+/CD8+ T cells of PBMC and improved histological scores and the survival rate.
2 context sentences(design, population, supporting numbers)
Summary · context
Healthy Sprague-Dawley rats (n = 72) were randomly divided into four groups: control group, SAP group, and two TA1 treated groups.
Summary · context
SAP was induced by injection of 5% sterile sodium taurocholate into the biliopancreatic duct (BPD), after which TA1 was given subcutaneously at 0 and 2 h at a dose of 100 microg/kg.
Report a problemFND-1791496106
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with severe acute pancreatitis, thymosin alpha‑1 improved the survival rate assessed 72 h after induction.
In plain wordsIn rats with severe pancreatitis, thymosin alpha‑1 improved survival at 72 hours.
Peptide
Thymosin alpha-1
Outcome
IncreaseSurvival rate at 72 h
Study
ratn = 30
sodium taurocholate-induced severe acute pancreatitis (SAP)
Comparator
SAP group
Outcome group
Mortality · Gastrointestinal
Studied dose
100 microg/kg · subcutaneous · 2 doses, at 0 and 2 hAs given in this study (rat).
Source sentences
Summary
Application of TA1 significantly balanced CD3/CD4+/CD8+ T cells of PBMC and improved histological scores and the survival rate.
1 context sentence(design, population, supporting numbers)
Summary · context
Next, 30 rats were randomly divided into three groups (each group containing 10 animals): SAP group (S) and two TA1 treated groups. The effects of TA1 on the survival of SAP were assessed 72 h after the induction of SAP.
Report a problemFND-1791496107

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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