Fast conventional Fmoc solid-phase peptide synthesis with HCTU.

Hood CA, Fuentes G, Patel H, Page K, Menakuru M, Park JH

Journal of peptide science : an official publication of the European Peptide Society1 Jan 2008Cited by 107 (Europe PMC)

PMID17890639DOI10.1002/psc.921PepBankPUB-17890639

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

01LabNot a test of GHRP-6 aloneIn vitro (cell-free)Other
In chemical synthesis including GHRP‑6, HCTU reduced deprotection times to 3 minutes or less.
In plain wordsIn lab tests including GHRP‑6 synthesis, HCTU reduced deprotection times to 3 minutes or less.
Peptide
GHRP-6
Outcome
DecreaseDeprotection time
Study
n: not reported in source
Outcome group
Synthesis and manufacturing · Pharmacology
Measurements
Deprotection time
≤ 3 min
HCTU synthesis
Source sentences
Summary
Seven biologically active peptides (GHRP-6, (65-74)ACP, oxytocin, G-LHRH, C-peptide, hAmylin(1-37), and beta-amyloid(1-42)) were synthesized with reaction times reduced to deprotection times of 3 min or less and coupling times of 5 min or less using HCTU as the coupling reagent.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1789063901
02LabNot a test of Oxytocin aloneIn vitro (cell-free)Other
In chemical synthesis including oxytocin, HCTU reduced deprotection times to 3 minutes or less.
In plain wordsIn lab tests including oxytocin synthesis, HCTU reduced deprotection times to 3 minutes or less.
Peptide
Oxytocin
Outcome
DecreaseDeprotection time
Study
n: not reported in source
Outcome group
Synthesis and manufacturing · Pharmacology
Measurements
Deprotection time
≤ 3 min
HCTU synthesis
Source sentences
Summary
Seven biologically active peptides (GHRP-6, (65-74)ACP, oxytocin, G-LHRH, C-peptide, hAmylin(1-37), and beta-amyloid(1-42)) were synthesized with reaction times reduced to deprotection times of 3 min or less and coupling times of 5 min or less using HCTU as the coupling reagent.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1789063902
03LabNot a test of GHRP-6 aloneIn vitro (cell-free)Other
In chemical synthesis including GHRP‑6, HCTU reduced coupling times to 5 minutes or less.
In plain wordsIn lab tests including GHRP‑6 synthesis, HCTU reduced coupling times to 5 minutes or less.
Peptide
GHRP-6
Outcome
DecreaseCoupling time
Study
n: not reported in source
Outcome group
Synthesis and manufacturing · Pharmacology
Measurements
Coupling time
≤ 5 min
HCTU synthesis
Source sentences
Summary
Seven biologically active peptides (GHRP-6, (65-74)ACP, oxytocin, G-LHRH, C-peptide, hAmylin(1-37), and beta-amyloid(1-42)) were synthesized with reaction times reduced to deprotection times of 3 min or less and coupling times of 5 min or less using HCTU as the coupling reagent.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1789063903
04LabNot a test of Oxytocin aloneIn vitro (cell-free)Other
In chemical synthesis including oxytocin, HCTU reduced coupling times to 5 minutes or less.
In plain wordsIn lab tests including oxytocin synthesis, HCTU reduced coupling times to 5 minutes or less.
Peptide
Oxytocin
Outcome
DecreaseCoupling time
Study
n: not reported in source
Outcome group
Synthesis and manufacturing · Pharmacology
Measurements
Coupling time
≤ 5 min
HCTU synthesis
Source sentences
Summary
Seven biologically active peptides (GHRP-6, (65-74)ACP, oxytocin, G-LHRH, C-peptide, hAmylin(1-37), and beta-amyloid(1-42)) were synthesized with reaction times reduced to deprotection times of 3 min or less and coupling times of 5 min or less using HCTU as the coupling reagent.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1789063904
05LabNot a test of GHRP-6 aloneIn vitro (cell-free)Other
In peptide synthesis including GHRP‑6, total synthesis times decreased by as much as 42.5 h with HCTU.
In plain wordsIn lab tests including GHRP‑6 synthesis, HCTU reduced total synthesis times by as much as 42.5 h.
Peptide
GHRP-6
Outcome
DecreaseTotal synthesis time
Study
n: not reported in source
Outcome group
Synthesis and manufacturing · Pharmacology
Source sentences
Summary
Total peptide synthesis times were dramatically reduced by as much as 42.5 h (1.8 days) without reducing the crude peptide purities.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven biologically active peptides (GHRP-6, (65-74)ACP, oxytocin, G-LHRH, C-peptide, hAmylin(1-37), and beta-amyloid(1-42)) were synthesized with reaction times reduced to deprotection times of 3 min or less and coupling times of 5 min or less using HCTU as the coupling reagent.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1789063905
06LabNot a test of Oxytocin aloneIn vitro (cell-free)Other
In peptide synthesis including oxytocin, total synthesis times decreased by as much as 42.5 h with HCTU.
In plain wordsIn lab tests including oxytocin synthesis, HCTU reduced total synthesis times by as much as 42.5 h.
Peptide
Oxytocin
Outcome
DecreaseTotal synthesis time
Study
n: not reported in source
Outcome group
Synthesis and manufacturing · Pharmacology
Source sentences
Summary
Total peptide synthesis times were dramatically reduced by as much as 42.5 h (1.8 days) without reducing the crude peptide purities.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven biologically active peptides (GHRP-6, (65-74)ACP, oxytocin, G-LHRH, C-peptide, hAmylin(1-37), and beta-amyloid(1-42)) were synthesized with reaction times reduced to deprotection times of 3 min or less and coupling times of 5 min or less using HCTU as the coupling reagent.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1789063906
07LabNot a test of GHRP-6 aloneIn vitro (cell-free)Other
In peptide synthesis including GHRP‑6, faster HCTU synthesis did not reduce crude peptide purities.
In plain wordsIn lab tests including GHRP‑6 synthesis, faster HCTU synthesis did not reduce crude peptide purities.
Peptide
GHRP-6
Outcome
No significant changeCrude peptide purity
Study
n: not reported in source
Outcome group
Synthesis and manufacturing · Pharmacology
Source sentences
Summary
Total peptide synthesis times were dramatically reduced by as much as 42.5 h (1.8 days) without reducing the crude peptide purities.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven biologically active peptides (GHRP-6, (65-74)ACP, oxytocin, G-LHRH, C-peptide, hAmylin(1-37), and beta-amyloid(1-42)) were synthesized with reaction times reduced to deprotection times of 3 min or less and coupling times of 5 min or less using HCTU as the coupling reagent.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1789063907
08LabNot a test of Oxytocin aloneIn vitro (cell-free)Other
In peptide synthesis including oxytocin, faster HCTU synthesis did not reduce crude peptide purities.
In plain wordsIn lab tests including oxytocin synthesis, faster HCTU synthesis did not reduce crude peptide purities.
Peptide
Oxytocin
Outcome
No significant changeCrude peptide purity
Study
n: not reported in source
Outcome group
Synthesis and manufacturing · Pharmacology
Source sentences
Summary
Total peptide synthesis times were dramatically reduced by as much as 42.5 h (1.8 days) without reducing the crude peptide purities.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven biologically active peptides (GHRP-6, (65-74)ACP, oxytocin, G-LHRH, C-peptide, hAmylin(1-37), and beta-amyloid(1-42)) were synthesized with reaction times reduced to deprotection times of 3 min or less and coupling times of 5 min or less using HCTU as the coupling reagent.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1789063908

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
9 Oct 2026, 03:13 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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