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Study · Animal study (in vivo) · rat · 2007

1 result

[Design and synthesis of cholecystokinin-4 dipeptide analogues with anxiolytic and anxiogenic activities].

Gudasheva TA, Kir'ianova EP, Kolik LG, Konstantinopol'skiĭ MA, Seredenin SB

Bioorganicheskaia khimiia1 Jul 2007Cited by 4 (Europe PMC)

PMID17886432 (opens in a new tab)DOI10.1134/s1068162007040036 (opens in a new tab)PepBankPUB-17886432
Publisher pagePubMedAsk about this study
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, GB‑115 showed anxiolytic activity at 0.05-0.2 mg/kg after oral and intraperitoneal administration.

    In plain wordsIn rats, GB‑115 showed anxiety-reducing activity after oral and intraperitoneal administration.

    Peptide
    GB-115
    Outcome
    DecreaseAnxiolytic activity
    Study

    ratn: not reported in source

    Anxiolytic activity study
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.05-0.2 mg/kg · oral and intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The dipeptide Ph(CH2)5CO-Gly-L-Trp-NH2 (GB-115) with the activity in rats of 0.05-0.2 mg/kg after oral and intraperitoneal administration was chosen for further studies as a promising anxiolytic agent.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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