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Study · Non-randomized trial · n = 58 · 2007

4 results

Effect of French maritime pine bark extract on endometriosis as compared with leuprorelin acetate.

Kohama T, Herai K, Inoue M

The Journal of reproductive medicine1 Aug 2007Cited by 19 (Europe PMC)

PMID17879831 (opens in a new tab)PepBankPUB-17879831
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In women with endometriosis, leuprorelin reduced symptom scores more efficiently than Pycnogenol.

    In plain wordsIn women with endometriosis, leuprorelin reduced symptom scores more efficiently than Pycnogenol.

    Peptide
    Leuprolide
    Outcome
    DecreaseSymptom scores
    Study

    n = 58

    Comparator
    Pycnogenol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with Gn-RHa reduced the scores more efficiently; however, 24 weeks after the end of treatment, the scores suggested a recurrence of signs.
    5 context sentences
    Title · context
    Effect of French maritime pine bark extract on endometriosis as compared with leuprorelin acetate.
    Summary · context
    Fifty-eight women were included in this study.
    Summary · context
    They were operated on conservatively for endometriosis and surgically diagnosed with the condition.
    Summary · context
    Thirty-two patients in the Pycnogenol treatment group took 60 mg Pycnogenol orally a day for 48 weeks.
    Summary · context
    The 26 patients who received gonadotropin-releasing hormone agonist (Gn-RHa) were treated in the standard way.
  2. 02HumanNon-randomized trialEfficacy outcome

    In women with endometriosis, CA-125 reduction was more pronounced with leuprorelin than Pycnogenol.

    In plain wordsIn women with endometriosis, CA-125 reduction was more pronounced with leuprorelin than Pycnogenol.

    Peptide
    Leuprolide
    Outcome
    DecreaseCA-125 reduction
    Study

    n = 58

    Comparator
    Pycnogenol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the Gn-RHa group, the lowering of CA-125 concentrations was far more pronounced; however, a clear rebound effect was observed.
    5 context sentences
    Title · context
    Effect of French maritime pine bark extract on endometriosis as compared with leuprorelin acetate.
    Summary · context
    Fifty-eight women were included in this study.
    Summary · context
    They were operated on conservatively for endometriosis and surgically diagnosed with the condition.
    Summary · context
    Thirty-two patients in the Pycnogenol treatment group took 60 mg Pycnogenol orally a day for 48 weeks.
    Summary · context
    The 26 patients who received gonadotropin-releasing hormone agonist (Gn-RHa) were treated in the standard way.
  3. 03HumanNon-randomized trialEfficacy outcome

    In women with endometriosis, symptom scores suggested recurrence 24 weeks after leuprorelin treatment ended.

    In plain wordsIn women with endometriosis, symptom scores suggested recurrence 24 weeks after leuprorelin treatment ended.

    Peptide
    Leuprolide
    Outcome
    IncreaseSymptom recurrence
    Study

    n = 26

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with Gn-RHa reduced the scores more efficiently; however, 24 weeks after the end of treatment, the scores suggested a recurrence of signs.
    5 context sentences
    Title · context
    Effect of French maritime pine bark extract on endometriosis as compared with leuprorelin acetate.
    Summary · context
    Fifty-eight women were included in this study.
    Summary · context
    They were operated on conservatively for endometriosis and surgically diagnosed with the condition.
    Summary · context
    Thirty-two patients in the Pycnogenol treatment group took 60 mg Pycnogenol orally a day for 48 weeks.
    Summary · context
    The 26 patients who received gonadotropin-releasing hormone agonist (Gn-RHa) were treated in the standard way.
  4. 04HumanNon-randomized trialEfficacy outcome

    In women with endometriosis, CA-125 showed a clear rebound after its reduction with leuprorelin.

    In plain wordsIn women with endometriosis, CA-125 showed a rebound after its reduction with leuprorelin.

    Peptide
    Leuprolide
    Outcome
    IncreaseCA-125 rebound
    Study

    n = 26

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the Gn-RHa group, the lowering of CA-125 concentrations was far more pronounced; however, a clear rebound effect was observed.
    5 context sentences
    Title · context
    Effect of French maritime pine bark extract on endometriosis as compared with leuprorelin acetate.
    Summary · context
    Fifty-eight women were included in this study.
    Summary · context
    They were operated on conservatively for endometriosis and surgically diagnosed with the condition.
    Summary · context
    Thirty-two patients in the Pycnogenol treatment group took 60 mg Pycnogenol orally a day for 48 weeks.
    Summary · context
    The 26 patients who received gonadotropin-releasing hormone agonist (Gn-RHa) were treated in the standard way.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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