NAP protects hippocampal neurons against multiple toxins.

Zemlyak I, Manley N, Sapolsky R, Gozes I

Peptides11 Aug 2007Cited by 27 (Europe PMC)

PMID17869381DOI10.1016/j.peptides.2007.08.004PepBankPUB-17869381

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In rat hippocampal cultures, NAP completely protected against oxygen-glucose deprivation.
In plain wordsIn cells from rat hippocampus, NAP completely protected against oxygen-glucose deprivation.
Peptide
Davunetide
Outcome
DecreaseOxygen-glucose deprivation injury
Study
ratn: not reported in source
Primary rat hippocampal cultures
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Femtomolar concentrationsAs given in this study (rat).
Source sentences
Summary
Results showed that NAP, at femtomolar concentrations, completely protected against oxygen-glucose deprivation, and cyanide poisoning.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have extended previous results and examined the protective potential of NAP in primary rat hippocampal cultures, using microtubule-associated protein 2 (MAP2) as a measure for neuroprotection.
Report a problemFND-1786938101
02LabIn vitro (cells)Efficacy outcome
In rat hippocampal cultures, NAP completely protected against cyanide poisoning.
In plain wordsIn cells from rat hippocampus, NAP completely protected against cyanide poisoning.
Peptide
Davunetide
Outcome
DecreaseCyanide poisoning injury
Study
ratn: not reported in source
Primary rat hippocampal cultures
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Femtomolar concentrationsAs given in this study (rat).
Source sentences
Summary
Results showed that NAP, at femtomolar concentrations, completely protected against oxygen-glucose deprivation, and cyanide poisoning.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have extended previous results and examined the protective potential of NAP in primary rat hippocampal cultures, using microtubule-associated protein 2 (MAP2) as a measure for neuroprotection.
Report a problemFND-1786938102
03LabIn vitro (cells)Efficacy outcome
In rat hippocampal cultures, NAP partially protected against kainic acid excitotoxicity.
In plain wordsIn cells from rat hippocampus, NAP partly protected against kainic acid toxicity.
Peptide
Davunetide
Outcome
DecreaseKainic acid excitotoxicity
Study
ratn: not reported in source
Primary rat hippocampal cultures
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, NAP partially protected against kainic acid excitotoxicity.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we have extended previous results and examined the protective potential of NAP in primary rat hippocampal cultures, using microtubule-associated protein 2 (MAP2) as a measure for neuroprotection.
Report a problemFND-1786938103

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

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