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Study · Animal study (in vivo) · rat · 2007

3 results

[Effects of chronic Semax administration on exploratory activity and emotional reaction in white rats].

Vilenskiĭ DA, Levitskaia NG, Andreeva LA, Alfeeva LIu, Kamenskiĭ AA, Miasoedov NF

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Jun 2007Cited by 4 (Europe PMC)

PMID17850024 (opens in a new tab)PepBankPUB-17850024
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In white rats, chronic intranasal Semax induced anxiolytic effects after 1 to 2 weeks.

    In plain wordsIn rats, Semax given through the nose for 1 to 2 weeks reduced anxiety-like behaviour.

    Peptide
    Semax
    Outcome
    DecreaseAnxiety level
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.05 mg/kg · intranasal · 10 or 14 daysAs given in this study (rat).

    Source sentences

    Summary
    It was shown that chronic Semax administration at 1-2 weeks induced anxiolytic and antidepressant effects but did not influenced the exploratory activity in non-stressogenic environment.
    2 context sentences
    Summary · context
    Effects of chronic intranasal administration of ACTH(4-10) analog Semax (MEHFPGP) on exploratory activity, anxiety level, and depression-like behaviour were studied in white rats.
    Summary · context
    The peptide was injected daily in dose 0.05 mg/kg during 10 or 14 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In white rats, chronic intranasal Semax induced antidepressant effects after 1 to 2 weeks.

    In plain wordsIn rats, Semax given through the nose for 1 to 2 weeks reduced depression-like behaviour.

    Peptide
    Semax
    Outcome
    DecreaseDepression-like behaviour
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.05 mg/kg · intranasal · 10 or 14 daysAs given in this study (rat).

    Source sentences

    Summary
    It was shown that chronic Semax administration at 1-2 weeks induced anxiolytic and antidepressant effects but did not influenced the exploratory activity in non-stressogenic environment.
    2 context sentences
    Summary · context
    Effects of chronic intranasal administration of ACTH(4-10) analog Semax (MEHFPGP) on exploratory activity, anxiety level, and depression-like behaviour were studied in white rats.
    Summary · context
    The peptide was injected daily in dose 0.05 mg/kg during 10 or 14 days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In white rats, chronic intranasal Semax did not influence exploratory activity in a non-stressogenic environment.

    In plain wordsIn rats, Semax given through the nose for 1 to 2 weeks did not change exploring behaviour in a calm setting.

    Peptide
    Semax
    Outcome
    No significant changeExploratory activity in non-stressogenic environment
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    0.05 mg/kg · intranasal · 10 or 14 daysAs given in this study (rat).

    Source sentences

    Summary
    It was shown that chronic Semax administration at 1-2 weeks induced anxiolytic and antidepressant effects but did not influenced the exploratory activity in non-stressogenic environment.
    2 context sentences
    Summary · context
    Effects of chronic intranasal administration of ACTH(4-10) analog Semax (MEHFPGP) on exploratory activity, anxiety level, and depression-like behaviour were studied in white rats.
    Summary · context
    The peptide was injected daily in dose 0.05 mg/kg during 10 or 14 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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