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Study · Animal study (in vivo) · mouse · 2007

5 results

A synthetic mechano growth factor E Peptide enhances myogenic precursor cell transplantation success.

Mills P, Dominique JC, Lafrenière JF, Bouchentouf M, Tremblay JP

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons1 Oct 2007Cited by 32 (Europe PMC)

PMID17845560 (opens in a new tab)DOI10.1111/j.1600-6143.2007.01927.x (opens in a new tab)PepBankPUB-17845560
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In mice transplanted with human myogenic precursor cells, intramuscular or systemic delivery of the synthetic MGF-Ct24E peptide significantly promoted engraftment.

    In plain wordsIn mice, the lab-made MGF peptide helped transplanted human muscle precursor cells to engraft.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseEngraftment of human myogenic precursor cells in mice
    Study

    mousen: not reported in source

    Mice transplanted with human myogenic precursor cells
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · intramuscular or systemicAs given in this study (mouse).

    Source sentences

    Summary
    Indeed, intramuscular or systemic delivery of this synthetic peptide significantly promoted engraftment of human MPCs in mice.
    1 context sentence
    Summary · context
    A 24 amino acids peptide corresponding to the C-terminal part of the MGF E domain (MGF-Ct24E peptide) was synthesized.
  2. 02LabIn vitro (cells)Activity measurement

    In human myogenic precursor cells in vitro, the MGF-Ct24E peptide enhanced proliferation by a mechanism other than binding to the IGF-1 receptor.

    In plain wordsIn cells, the MGF peptide increased human muscle precursor cell growth, apparently without the IGF-1 receptor.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseProliferation of human myogenic precursor cells
    Study

    humann: not reported in source

    Human myogenic precursor cells
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro experiments demonstrated that the MGF-Ct24E peptide enhanced MPC proliferation by a different mechanism than the binding to the IGF-1 receptor.
    1 context sentence
    Summary · context
    A 24 amino acids peptide corresponding to the C-terminal part of the MGF E domain (MGF-Ct24E peptide) was synthesized.
  3. 03LabIn vitro (cells)Mechanism

    In human myogenic precursor cells in vitro, the proliferation effect of the MGF-Ct24E peptide differed from binding to the IGF-1 receptor.

    In plain wordsIn cells, the MGF peptide acted by a route other than the IGF-1 receptor.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableIGF-1 receptor independence of proliferation
    Study

    humann: not reported in source

    Human myogenic precursor cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro experiments demonstrated that the MGF-Ct24E peptide enhanced MPC proliferation by a different mechanism than the binding to the IGF-1 receptor.
    1 context sentence
    Summary · context
    A 24 amino acids peptide corresponding to the C-terminal part of the MGF E domain (MGF-Ct24E peptide) was synthesized.
  4. 04LabIn vitro (cells)Activity measurement

    In human myogenic precursor cells, the MGF-Ct24E peptide delayed differentiation.

    In plain wordsIn cells, the MGF peptide slowed the maturation of human muscle precursor cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseDifferentiation of human myogenic precursor cells
    Study

    humann: not reported in source

    Human myogenic precursor cells
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, MGF-Ct24E peptide delayed human MPC differentiation while having no outcome on survival.
    1 context sentence
    Summary · context
    A 24 amino acids peptide corresponding to the C-terminal part of the MGF E domain (MGF-Ct24E peptide) was synthesized.
  5. 05LabIn vitro (cells)Activity measurement

    In human myogenic precursor cells, the MGF-Ct24E peptide had no effect on survival.

    In plain wordsIn cells, the MGF peptide did not change the survival of human muscle precursor cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeSurvival of human myogenic precursor cells
    Study

    humann: not reported in source

    Human myogenic precursor cells
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, MGF-Ct24E peptide delayed human MPC differentiation while having no outcome on survival.
    1 context sentence
    Summary · context
    A 24 amino acids peptide corresponding to the C-terminal part of the MGF E domain (MGF-Ct24E peptide) was synthesized.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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