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Study · Measured the body's own peptide · 2007

2 results

Changes in vasoactive intestinal peptide and arginine vasopressin expression in the suprachiasmatic nucleus of the rat brain following footshock stress.

Handa RJ, Zoeller RT, McGivern RF

Neuroscience letters25 Aug 2007Cited by 11 (Europe PMC)

PMID17826907 (opens in a new tab)PMCIDPMC2048536 (opens in a new tab)DOI10.1016/j.neulet.2007.08.044 (opens in a new tab)PepBankPUB-17826907
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Efficacy outcome

    In rats, footshock stress decreased the number of cells expressing the body's own VIP mRNA in the suprachiasmatic nucleus.

    In plain wordsIn rats, footshock stress reduced the number of brain clock cells making the body's own VIP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseNumber of cells expressing VIP mRNA in the SCN
    Study

    ratn: not reported in source

    Footshock stress; in situ hybridization of suprachiasmatic nucleus
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    In contrast, footshock stress decreased the number of cells expressing VIP mRNA in the SCN
    2 context sentences
    Summary · context
    Young adult male Sprague/Dawley rats were subjected to 15 s of scrambled intermittent footshock (0.50 mA pulses, 1 pulse/s, 300 ms duration) every 5 min for 30 min.
    Summary · context
    Animals were sacrificed 75 or 135 min after the onset of stress and brains examined for AVP mRNA and hnRNA, and VIP mRNA using in situ hybridization.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Efficacy outcome

    In rats, footshock stress did not change the VIP mRNA hybridization level per cell in the suprachiasmatic nucleus.

    In plain wordsIn rats, footshock stress did not change how much of the body's own VIP message each clock cell made.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeVIP mRNA hybridization level per cell in the SCN
    Study

    ratn: not reported in source

    Footshock stress; in situ hybridization of suprachiasmatic nucleus
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    footshock stress decreased the number of cells expressing VIP mRNA in the SCN without changing hybridization level per cell.
    2 context sentences
    Summary · context
    Young adult male Sprague/Dawley rats were subjected to 15 s of scrambled intermittent footshock (0.50 mA pulses, 1 pulse/s, 300 ms duration) every 5 min for 30 min.
    Summary · context
    Animals were sacrificed 75 or 135 min after the onset of stress and brains examined for AVP mRNA and hnRNA, and VIP mRNA using in situ hybridization.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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