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Study · Animal study (in vivo) · siberian hamster · 2007

4 results

MTII attenuates ghrelin- and food deprivation-induced increases in food hoarding and food intake.

Keen-Rhinehart E, Bartness TJ

Hormones and behavior10 Aug 2007Cited by 24 (Europe PMC)

PMID17826779 (opens in a new tab)PMCIDPMC2121140 (opens in a new tab)DOI10.1016/j.yhbeh.2007.07.014 (opens in a new tab)PepBankPUB-17826779
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Siberian hamsters, concurrent MTII injections completely blocked the food deprivation-induced increase in food intake.

    In plain wordsIn hamsters, Melanotan II fully blocked the rise in eating caused by food deprivation.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood deprivation-induced increase in food intake
    Study

    Siberian hamstern: not reported in source

    Food-deprived, fed or ghrelin-injected hamsters in a running wheel foraging system
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (3rd ventricle)As given in this study (Siberian hamster).

    Source sentences

    Summary
    Concurrent injections of MTII completely blocked food deprivation- and ghrelin-induced increases in food intake
    1 context sentence
    Summary · context
    This was accomplished by injecting melanotan II (MTII), a synthetic MC3/4-R agonist, into the 3rd ventricle in food deprived, fed or peripheral ghrelin injected hamsters and housed in a running wheel-based food delivery foraging system.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Siberian hamsters, concurrent MTII injections completely blocked the ghrelin-induced increase in food intake.

    In plain wordsIn hamsters, Melanotan II fully blocked the rise in eating caused by ghrelin.

    Peptide
    Melanotan II
    Outcome
    DecreaseGhrelin-induced increase in food intake
    Study

    Siberian hamstern: not reported in source

    Food-deprived, fed or ghrelin-injected hamsters in a running wheel foraging system
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (3rd ventricle)As given in this study (Siberian hamster).

    Source sentences

    Summary
    Concurrent injections of MTII completely blocked food deprivation- and ghrelin-induced increases in food intake
    1 context sentence
    Summary · context
    This was accomplished by injecting melanotan II (MTII), a synthetic MC3/4-R agonist, into the 3rd ventricle in food deprived, fed or peripheral ghrelin injected hamsters and housed in a running wheel-based food delivery foraging system.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Siberian hamsters, MTII attenuated, but did not always completely block, the food deprivation-induced increase in food hoarding.

    In plain wordsIn hamsters, Melanotan II reduced, but not always fully blocked, the rise in food hoarding caused by food deprivation.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood deprivation-induced increase in food hoarding
    Study

    Siberian hamstern: not reported in source

    Food-deprived, fed or ghrelin-injected hamsters in a running wheel foraging system
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (3rd ventricle)As given in this study (Siberian hamster).

    Source sentences

    Summary
    and attenuated, but did not always completely block, food deprivation- and ghrelin-induced increases in food hoarding.
    1 context sentence
    Summary · context
    This was accomplished by injecting melanotan II (MTII), a synthetic MC3/4-R agonist, into the 3rd ventricle in food deprived, fed or peripheral ghrelin injected hamsters and housed in a running wheel-based food delivery foraging system.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In Siberian hamsters, MTII attenuated, but did not always completely block, the ghrelin-induced increase in food hoarding.

    In plain wordsIn hamsters, Melanotan II reduced, but not always fully blocked, the rise in food hoarding caused by ghrelin.

    Peptide
    Melanotan II
    Outcome
    DecreaseGhrelin-induced increase in food hoarding
    Study

    Siberian hamstern: not reported in source

    Food-deprived, fed or ghrelin-injected hamsters in a running wheel foraging system
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (3rd ventricle)As given in this study (Siberian hamster).

    Source sentences

    Summary
    and attenuated, but did not always completely block, food deprivation- and ghrelin-induced increases in food hoarding.
    1 context sentence
    Summary · context
    This was accomplished by injecting melanotan II (MTII), a synthetic MC3/4-R agonist, into the 3rd ventricle in food deprived, fed or peripheral ghrelin injected hamsters and housed in a running wheel-based food delivery foraging system.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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