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Study · Animal study (in vivo) · mouse · 2007

4 results

Thymosin alpha1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo.

Bozza S, Gaziano R, Bonifazi P, Zelante T, Pitzurra L, Montagnoli C, Moretti S, Castronari R, Sinibaldi P, Rasi G, Garaci E, Bistoni F, Romani L

International immunology5 Sept 2007Cited by 46 (Europe PMC)

PMID17804687 (opens in a new tab)DOI10.1093/intimm/dxm097 (opens in a new tab)PepBankPUB-17804687
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In susceptible and resistant mice infected with murine cytomegalovirus, thymosin alpha‑1 protected the animals from infection.

    In plain wordsIn mice infected with murine cytomegalovirus, thymosin alpha‑1 protected both susceptible and resistant animals from infection.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableProtection from MCMV infection
    Study

    mousen: not reported in source

    murine cytomegalovirus (MCMV) infection in susceptible, resistant and TLR-deficient mice
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Talpha1 protected susceptible and resistant mice from MCMV infection.
    1 context sentence
    Summary · context
    To this purpose, susceptible, resistant and TLR-deficient mice were infected with MCMV, treated with Talpha1 and assessed for protection in term of microbiological and immunological parameters.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In MCMV-infected mice, the antiviral effect of thymosin alpha‑1 occurred through activation of plasmacytoid dendritic cells by TLR9/MyD88-dependent viral sensing.

    In plain wordsIn mice with murine cytomegalovirus, thymosin alpha‑1 acted by activating plasmacytoid dendritic cells through a TLR9 and MyD88 pathway.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePlasmacytoid dendritic cell activation via TLR9/MyD88
    Study

    mousen: not reported in source

    murine cytomegalovirus (MCMV) infection in susceptible, resistant and TLR-deficient mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The anti-viral effect of Talpha1 occurred through the activation of plasmacytoid DCs via the TLR9/myeloid differentiation primary response gene 88-dependent viral recognition sensing, leading to the activation of IFN regulatory factor 7 and the promotion of the IFN-alpha/IFN-gamma-dependent effector pathway.
    1 context sentence
    Summary · context
    To this purpose, susceptible, resistant and TLR-deficient mice were infected with MCMV, treated with Talpha1 and assessed for protection in term of microbiological and immunological parameters.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In MCMV-infected mice, thymosin alpha‑1 led to activation of IFN regulatory factor 7.

    In plain wordsIn mice with murine cytomegalovirus, thymosin alpha‑1 led to activation of the antiviral signalling protein IRF7.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseIRF7 activation
    Study

    mousen: not reported in source

    murine cytomegalovirus (MCMV) infection in susceptible, resistant and TLR-deficient mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The anti-viral effect of Talpha1 occurred through the activation of plasmacytoid DCs via the TLR9/myeloid differentiation primary response gene 88-dependent viral recognition sensing, leading to the activation of IFN regulatory factor 7 and the promotion of the IFN-alpha/IFN-gamma-dependent effector pathway.
    1 context sentence
    Summary · context
    To this purpose, susceptible, resistant and TLR-deficient mice were infected with MCMV, treated with Talpha1 and assessed for protection in term of microbiological and immunological parameters.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In MCMV-infected mice, thymosin alpha‑1 promoted the IFN-alpha/IFN-gamma-dependent effector pathway.

    In plain wordsIn mice with murine cytomegalovirus, thymosin alpha‑1 promoted an interferon-dependent antiviral pathway.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseIFN-alpha/IFN-gamma-dependent effector pathway
    Study

    mousen: not reported in source

    murine cytomegalovirus (MCMV) infection in susceptible, resistant and TLR-deficient mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The anti-viral effect of Talpha1 occurred through the activation of plasmacytoid DCs via the TLR9/myeloid differentiation primary response gene 88-dependent viral recognition sensing, leading to the activation of IFN regulatory factor 7 and the promotion of the IFN-alpha/IFN-gamma-dependent effector pathway.
    1 context sentence
    Summary · context
    To this purpose, susceptible, resistant and TLR-deficient mice were infected with MCMV, treated with Talpha1 and assessed for protection in term of microbiological and immunological parameters.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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