Enhancement of graft bone healing by intermittent administration of human parathyroid hormone (1-34) in a rat spinal arthrodesis model.

Abe Y, Takahata M, Ito M, Irie K, Abumi K, Minami A

Bone13 Jul 2007Cited by 64 (Europe PMC)

PMID17707711DOI10.1016/j.bone.2007.06.025PepBankPUB-17707711

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased spinal fusion at day 14 to 57% versus 14% with control.
In plain wordsIn rats, PTH increased early spinal fusion compared with control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFusion rate at day 14
Study
ratn = 14
Male Sprague-Dawley rat spinal arthrodesis with autologous bone grafts
Comparator
Saline vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg/day · subcutaneous · From surgery until deathAs given in this study (rat).
Source sentences
Summary
PTH administration increased the fusion rate on day 14 (14% in the control group and 57% in the PTH group), accelerated grafted bone resorption, and produced a larger and denser fusion mass compared to control.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-two male Sprague-Dawley rats underwent posterolateral spinal arthrodesis surgery using autologous bone grafts.
Summary · context
Animals were given daily subcutaneous injections of hPTH(1-34) (40 microg/kg/day PTH group) or 0.9% saline vehicle (control group) from immediately after surgery till death.
Report a problemFND-1770771102
02AnimalAnimal study (in vivo)Efficacy outcome
In rats after spinal arthrodesis, PTH decreased the time required for graft bone healing versus control.
In plain wordsIn rats, PTH shortened graft bone healing time compared with control.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseTime to graft healing
Study
ratn: not reported in source
Male Sprague-Dawley rat spinal arthrodesis with autologous bone grafts
Comparator
Saline vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg/day · subcutaneous · From surgery until deathAs given in this study (rat).
Source sentences
Summary
The results indicated that PTH administration decreased the time required for graft bone healing and provided a structurally superior fusion mass in the rat spinal arthrodesis model.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-two male Sprague-Dawley rats underwent posterolateral spinal arthrodesis surgery using autologous bone grafts.
Summary · context
Animals were given daily subcutaneous injections of hPTH(1-34) (40 microg/kg/day PTH group) or 0.9% saline vehicle (control group) from immediately after surgery till death.
Report a problemFND-1770771101
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH accelerated grafted bone resorption versus control.
In plain wordsIn rats, PTH accelerated graft bone resorption compared with control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseGrafted bone resorption
Study
ratn: not reported in source
Male Sprague-Dawley rat spinal arthrodesis with autologous bone grafts
Comparator
Saline vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg/day · subcutaneous · From surgery until deathAs given in this study (rat).
Source sentences
Summary
PTH administration increased the fusion rate on day 14 (14% in the control group and 57% in the PTH group), accelerated grafted bone resorption, and produced a larger and denser fusion mass compared to control.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-two male Sprague-Dawley rats underwent posterolateral spinal arthrodesis surgery using autologous bone grafts.
Summary · context
Animals were given daily subcutaneous injections of hPTH(1-34) (40 microg/kg/day PTH group) or 0.9% saline vehicle (control group) from immediately after surgery till death.
Report a problemFND-1770771103
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH produced a larger spinal fusion mass versus control.
In plain wordsIn rats, PTH produced a larger fusion mass compared with control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFusion mass size
Study
ratn: not reported in source
Male Sprague-Dawley rat spinal arthrodesis with autologous bone grafts
Comparator
Saline vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg/day · subcutaneous · From surgery until deathAs given in this study (rat).
Source sentences
Summary
PTH administration increased the fusion rate on day 14 (14% in the control group and 57% in the PTH group), accelerated grafted bone resorption, and produced a larger and denser fusion mass compared to control.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-two male Sprague-Dawley rats underwent posterolateral spinal arthrodesis surgery using autologous bone grafts.
Summary · context
Animals were given daily subcutaneous injections of hPTH(1-34) (40 microg/kg/day PTH group) or 0.9% saline vehicle (control group) from immediately after surgery till death.
Report a problemFND-1770771104
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH produced a denser spinal fusion mass versus control.
In plain wordsIn rats, PTH produced a denser fusion mass compared with control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFusion mass density
Study
ratn: not reported in source
Male Sprague-Dawley rat spinal arthrodesis with autologous bone grafts
Comparator
Saline vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg/day · subcutaneous · From surgery until deathAs given in this study (rat).
Source sentences
Summary
PTH administration increased the fusion rate on day 14 (14% in the control group and 57% in the PTH group), accelerated grafted bone resorption, and produced a larger and denser fusion mass compared to control.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-two male Sprague-Dawley rats underwent posterolateral spinal arthrodesis surgery using autologous bone grafts.
Summary · context
Animals were given daily subcutaneous injections of hPTH(1-34) (40 microg/kg/day PTH group) or 0.9% saline vehicle (control group) from immediately after surgery till death.
Report a problemFND-1770771105
06AnimalAnimal study (in vivo)Mechanism
In rats, PTH increased osteoblast-related mRNA expression versus control.
In plain wordsIn rats, PTH increased bone-forming cell gene expression compared with control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseOsteoblast-related gene expression
Study
ratn: not reported in source
Male Sprague-Dawley rat spinal arthrodesis with autologous bone grafts
Comparator
Saline vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg/day · subcutaneous · From surgery until deathAs given in this study (rat).
Source sentences
Summary
mRNA expression of both osteoblast- and osteoclast-related genes was upregulated by PTH treatment,
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-two male Sprague-Dawley rats underwent posterolateral spinal arthrodesis surgery using autologous bone grafts.
Summary · context
Animals were given daily subcutaneous injections of hPTH(1-34) (40 microg/kg/day PTH group) or 0.9% saline vehicle (control group) from immediately after surgery till death.
Report a problemFND-1770771106
07AnimalAnimal study (in vivo)Mechanism
In rats, PTH increased osteoclast-related mRNA expression versus control.
In plain wordsIn rats, PTH increased bone-resorbing cell gene expression compared with control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseOsteoclast-related gene expression
Study
ratn: not reported in source
Male Sprague-Dawley rat spinal arthrodesis with autologous bone grafts
Comparator
Saline vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg/day · subcutaneous · From surgery until deathAs given in this study (rat).
Source sentences
Summary
mRNA expression of both osteoblast- and osteoclast-related genes was upregulated by PTH treatment,
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-two male Sprague-Dawley rats underwent posterolateral spinal arthrodesis surgery using autologous bone grafts.
Summary · context
Animals were given daily subcutaneous injections of hPTH(1-34) (40 microg/kg/day PTH group) or 0.9% saline vehicle (control group) from immediately after surgery till death.
Report a problemFND-1770771107
08AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased serum bone formation markers versus control.
In plain wordsIn rats, PTH increased blood bone formation markers compared with control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSerum bone formation markers
Study
ratn: not reported in source
Male Sprague-Dawley rat spinal arthrodesis with autologous bone grafts
Comparator
Saline vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg/day · subcutaneous · From surgery until deathAs given in this study (rat).
Source sentences
Summary
and serum bone formation and resorption marker levels were higher in the PTH group than in the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-two male Sprague-Dawley rats underwent posterolateral spinal arthrodesis surgery using autologous bone grafts.
Summary · context
Animals were given daily subcutaneous injections of hPTH(1-34) (40 microg/kg/day PTH group) or 0.9% saline vehicle (control group) from immediately after surgery till death.
Report a problemFND-1770771108
09AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased serum bone resorption markers versus control.
In plain wordsIn rats, PTH increased blood bone resorption markers compared with control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSerum bone resorption markers
Study
ratn: not reported in source
Male Sprague-Dawley rat spinal arthrodesis with autologous bone grafts
Comparator
Saline vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg/day · subcutaneous · From surgery until deathAs given in this study (rat).
Source sentences
Summary
and serum bone formation and resorption marker levels were higher in the PTH group than in the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-two male Sprague-Dawley rats underwent posterolateral spinal arthrodesis surgery using autologous bone grafts.
Summary · context
Animals were given daily subcutaneous injections of hPTH(1-34) (40 microg/kg/day PTH group) or 0.9% saline vehicle (control group) from immediately after surgery till death.
Report a problemFND-1770771109
10AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased mineral apposition rate versus control.
In plain wordsIn rats, PTH increased bone mineral deposition rate compared with control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseMineral apposition rate
Study
ratn: not reported in source
Male Sprague-Dawley rat spinal arthrodesis with autologous bone grafts
Comparator
Saline vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg/day · subcutaneous · From surgery until deathAs given in this study (rat).
Source sentences
Summary
Histologically calculated mineral apposition rate, mineralized surface and osteoclast surface were also higher in the PTH group than in the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-two male Sprague-Dawley rats underwent posterolateral spinal arthrodesis surgery using autologous bone grafts.
Summary · context
Animals were given daily subcutaneous injections of hPTH(1-34) (40 microg/kg/day PTH group) or 0.9% saline vehicle (control group) from immediately after surgery till death.
Report a problemFND-1770771110
11AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased mineralized surface versus control.
In plain wordsIn rats, PTH increased mineralized bone surface compared with control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseMineralized surface
Study
ratn: not reported in source
Male Sprague-Dawley rat spinal arthrodesis with autologous bone grafts
Comparator
Saline vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg/day · subcutaneous · From surgery until deathAs given in this study (rat).
Source sentences
Summary
Histologically calculated mineral apposition rate, mineralized surface and osteoclast surface were also higher in the PTH group than in the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-two male Sprague-Dawley rats underwent posterolateral spinal arthrodesis surgery using autologous bone grafts.
Summary · context
Animals were given daily subcutaneous injections of hPTH(1-34) (40 microg/kg/day PTH group) or 0.9% saline vehicle (control group) from immediately after surgery till death.
Report a problemFND-1770771111
12AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased osteoclast surface versus control.
In plain wordsIn rats, PTH increased bone surface covered by bone-resorbing cells compared with control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseOsteoclast surface
Study
ratn: not reported in source
Male Sprague-Dawley rat spinal arthrodesis with autologous bone grafts
Comparator
Saline vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
40 microg/kg/day · subcutaneous · From surgery until deathAs given in this study (rat).
Source sentences
Summary
Histologically calculated mineral apposition rate, mineralized surface and osteoclast surface were also higher in the PTH group than in the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty-two male Sprague-Dawley rats underwent posterolateral spinal arthrodesis surgery using autologous bone grafts.
Summary · context
Animals were given daily subcutaneous injections of hPTH(1-34) (40 microg/kg/day PTH group) or 0.9% saline vehicle (control group) from immediately after surgery till death.
Report a problemFND-1770771112

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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